Prashanth, K.; Badrinath, S.
January 2006
Indian Journal of Medical Microbiology;Jan2006, Vol. 24 Issue 1, p39
Academic Journal
Purpose: Nosocomial infections caused by Acinetobacter species is of increasing concern in critically ill patients, and the risk factors for this infection are not well established. The present investigation was done to determine incidence of nosocomial Acinetobacter infections. Our study retrospectively attempts to find risk and prognostic factors for the nosocomial acquisition of Acinetobacter infection. Methods: The medical records of 43 patients with Acinetobacter infection during two-year period (Oct1998-Oct2000) were reviewed to find the factors involved in the nosocomial acquisition of Acinetobacter. Acinetobacter isolates that were obtained from these patients were phenotypically typed using carbon assimilation tests. Antimicrobial susceptibility testing results were noted from the microbiology records. Results: Acinetobacter baumannii accounted for 41.8% (n=18) of all the infections. By multivariate logistic regression analysis, only resistant antibiotype {(Ceftazidime- OR, 7.13 [95% CI, 1 to 46]; P= 0.044); (Cefotaxime- OR, 6.09 [CI, 0.87 to 30]; P = 0.045)} and mechanical ventilation (OR, 5.84 [CI, 0.83 to 31]; P = 0.05) were found to be potential independent risk factors for mortality. Overall mortality rate was 33%. Conclusions: Most of A. baumannii isolates were multidrug resistant in our set up and infections due to them were associated with high mortality. Prevention of Multiple drug resistant (MDR) A. baumannii infections was achieved after discontinuation of cefotaxime in ICU. Infection with resistant clones and mechanical ventilation were found to be potential independent risk factors for mortality.


Related Articles

  • An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii. Dijkshoorn, Lenie; Nemec, Alexandr; Seifert, Harald // Nature Reviews Microbiology;Dec2007, Vol. 5 Issue 12, p939 

    Since the 1970s, the spread of multidrug-resistant (MDR) Acinetobacter strains among critically ill, hospitalized patients, and subsequent epidemics, have become an increasing cause of concern. Reports of community-acquired Acinetobacter infections have also increased over the past decade. A...

  • Epidemiological investigation of nosocomial infection with multidrug-resistant Acinetobacter baumannii. EL-AGEERY, S. M.; ABO-SHADI, M. A.; ALGHAITHY, A. A.; AHMAD, M. A.; ALSHARIF, N. H.; ALHARBI, S. A. // European Review for Medical & Pharmacological Sciences;Nov2012, Vol. 16 Issue 13, p1834 

    BACKGROUND: Multidrug resistant Acinetobacter baumannii, (MRAB) is an important cause of hospital acquired infection. AIM: To document the emergence of MRAB in an Intensive Care Unit (ICU); and to characterize its hospital-wide outbreak by investigating antibiotypes and genotypes. MATERIALS AND...

  • Carbapenemase-producing Acinetobacter baumannii, Algeria. Drissi, M.; Poirel, L.; Mugnier, P.; Baba Ahmed, Z.; Nordmann, P. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2010, Vol. 29 Issue 11, p1457 

    No abstract available.

  • Endemic Acinetobacter baumannii in a New York Hospital. Weisenberg, Scott A.; Schuetz, Audrey N.; Alexander, Elizabeth A.; Eiss, Brain; Behta, Maryam; Saiman, Lisa; Larone, Davise H.; Jenkins, Stephen G.; Rhee, Kyu Y. // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    Background: Acinetobacter baumannii is an increasingly multidrug-resistant (MDR) cause of hospital-acquired infections, often associated with limited therapeutic options. We investigated A. baumannii isolates at a New York hospital to characterize genetic relatedness. Methods: Thirty A....

  • Mortalidad por Acinetobacter baumannii en unidades de cuidados intensivos en Colombia. Lemos, Elkin V.; De La Hoz Restrepo, Fernando; Alvis, Nelson; Quevedo, Elkin; Ca�on, Oscar; Le�n, Yazmin // Pan American Journal of Public Health;Oct2011, Vol. 30 Issue 4, p287 

    Objective. Compare mortality in multidrug-susceptible Acinetobacter baumannii-infected patients and multidrug-resistant A. baumannii-infected patients hospitalized in intensive care units (ICUs) in Colombia. Methods. A prospective, observational, and multicenter study. A total of 165 patients...

  • A Method for generating marker-less gene deletions in multidrug-resistant Acinetobacter baumannii. Amin, Ismawati Mohammad; Richmond, Grace E.; Sen, Paromita; Koh, Tse Hsien; Piddock, Laura J. V.; Kim Lee Chua // BMC Microbiology;2013, Vol. 13 Issue 1, p1 

    Background: Acinetobacter baumannii is an important nosocomial pathogen that has become increasingly resistant to multiple antibiotics. Genetic manipulation of MDR A. baumannii is useful especially for defining the contribution of each active efflux mechanism in multidrug resistance. Existing...

  • Acinetobacter baumannii. Howard, Aoife; O'Donoghue, Michael; Feeney, Audrey; Sleator, Roy D. // Virulence;May2012, Vol. 3 Issue 3, p243 

    Acinetobacter baumannii is an opportunistic bacterial pathogen primarily associated with hospital-acquired infections. The recent increase in incidence, largely associated with infected combat troops returning from conflict zones, coupled with a dramatic increase in the incidence of...

  • Multidrug-resistant acinetobacter infection and their susceptibility patterns in a tertiary care hospital. Rit, Kalidas; Saha, Rajdeep // Nigerian Medical Journal;Jul-Sep2012, Vol. 53 Issue 3, p126 

    Background: Antibiotic-resistant Acinetobacter nosocomial infection is a leading problem. It acts as an opportunistic pathogen to cause a wide spectrum of infection including nosocomial pneumonia, meningitis, endocarditis, skin and soft tissue infections, urinary tract infection, conjunctivitis,...

  • Frequency of Nosocomial Infections with Antibiotic Resistant Strains of Acinetobacter spp. in ICU Patients. Amini, Maryam; Davati, Ali; Golestanifard, Mahdieh // Iranian Journal of Pathology;Fall2012, Vol. 7 Issue 4, p241 

    Background and Objective: Acinetobacter spp. a Gram-negative coccobacillus is increasingly reported as important cause of nosocomial infections. Multi-drug resistance (MDR) of Acinetobacter spp., raises concerns over our ability to treat serious infections with these organisms. The aim of this...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics