Response to Empirical Anti-Tuberculosis Treatment in Patients with Sputum Smear-Negative Presumptive Pulmonary Tuberculosis

Chang-Hoon Lee; Woo Jin Kim; Chul-Gyu Yoo; Young Wham Kim; Sung Koo Han; Young-Soo Shim; Jae-Joon Yim
July 2005
Respiration;Jul/Aug2005, Vol. 72 Issue 4, p369
Academic Journal
Background: In many cases, physicians initiate anti-tuberculosis (TB) treatment based only on symptoms or radiographic findings without confirmation of pulmonary TB by acid-fast bacilli (AFB) smear. It has not been well known which clinical characteristics could be used as predictors for positive culture or real TB in patients with sputum smear-negative presumptive pulmonary TB. Objective: We tried to elucidate treatment outcomes in patients with sputum smear-negative presumptive pulmonary TB and to find predictors of positive culture results. Methods: We reviewed data of the patients who had been treated as presumptive TB with negative AFB smear on the basis of clinical and radiographic features from December 1998 to December 2000 at a university hospital in Korea. We reviewed medical records and radiographs of patients and analyzed possible predictors for positive culture. Results: One hundred and one patients were enrolled. Among them, pulmonary TB was confirmed by culture in 32 patients (31%). Thirty-one (96.9%) out of 32 culture-positive patients showed clinical or radiographic improvement as did 50 (72.5%) out of 69 culture-negative patients. The predictor for a positive culture result is the presence of patchy consolidation in an initial radiograph (p = 0.025; OR 2.89; 95% CI 1.14–7.28). Conclusions: The empirical anti-TB treatment in patients with sputum smear-negative presumptive pulmonary TB was effective and adequate, especially presented with patchy consolidation in initial chest radiographs in Korea. Copyright © 2005 S. Karger AG, Basel


Related Articles

  • In the Literature.  // Clinical Infectious Diseases;6/1/2005, Vol. 40 Issue 11, preceding p1559 

    The article presents papers related to infectious diseases that appear in the 2005 issue of the journal "Clinical Infectious Diseases." The paper "Diagnosis of Sputum-Scarce HIV-Associated Pulmonary Tuberculosis in Lima, Peru" describes about HIV-infected adults in Lima, Peru, with suspected...

  • Rats Detect Tuberculosis.  // Behavior Analysis Digest International;Summer2011, Vol. 23 Issue 2, preceding p6 

    The article discusses research on the ability of rats to detect tuberculosis. It references the study "Tuberculosis Detection by Giant African Pouched Rats," by A. Poling and his team, published in a 2011 issue of "The Behavior Analyst." The study found that rats are able to detect tuberculosis...

  • What 'outliers' tell us about missed opportunities for tuberculosis control: a cross-sectional study of patients in Mumbai, India. Pradhan, Anagha; Kielmann, Karina; Gupte, Himanshu; Bamne, Arun; Porter, John D. H.; Rangan, Sheela // BMC Public Health;2010, Vol. 10 Issue 1, p263 

    Background: India's Revised National Tuberculosis Control Programme (RNTCP) is deemed highly successful in terms of detection and cure rates. However, some patients experience delays in accessing diagnosis and treatment. Patients falling between the 96th and 100th percentiles for these access...

  • Progress towards the 2005 international targets for tuberculosis control.  // Weekly Epidemiological Record;5/18/2007, Vol. 82 Issue 20, p178 

    The article looks on the progress in implementing the Directly Observed Treatment, Short-course (DOTS) strategy for the control of tuberculosis (TB). The progress in implementing the said strategy has been assessed in relation to two targets set in 2005 for global TB control. Moreover, the two...

  • Evaluation of the Burden of Unsuspected Pulmonary Tuberculosis and Co-Morbidity with Non-Communicable Diseases in Sputum Producing Adult Inpatients. Bates, Matthew; O'Grady, Justin; Mwaba, Peter; Chilukutu, Lophina; Mzyece, Judith; Cheelo, Busiku; Chilufya, Moses; Mukonda, Lukundo; Mumba, Maxwell; Tembo, John; Chomba, Mumba; Kapata, Nathan; Rachow, Andrea; Clowes, Petra; Maeurer, Markus; Hoelscher, Michael; Zumla, Alimuddin // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    Background: A high burden of tuberculosis (TB) occurs in sub-Saharan African countries and many cases of active TB and drug-resistant TB remain undiagnosed. Tertiary care hospitals provide an opportunity to study TB co-morbidity with noncommunicable and other communicable diseases (NCDs/CDs). We...

  • Capacity of healthcare facilities in the implementation of Direct Observed Treatment strategy for tuberculosis in Arumeru and Karatu districts, Tanzania. MFINANGA, G. S.; NGADAYA, E.; KIMARO, G.; MTANDU, R.; LEMA, L. A.; BASRA, D.; LWILA, F.; EGWAGA, S.; KITUA, A. Y. // Tanzania Journal of Health Research;Jun2008, Vol. 10 Issue 2, p95 

    Directly Observed Treatment Short course strategy (DOTS) has proved to have potential improvement in tuberculosis (TB) control in Tanzania. The objective of this cross sectional study was to assess the capacity of health facilities in implementing DOTS, in Arumeru and Karatu districts, Tanzania....

  • DILEME ETICE ÃŽN ACTIVITATEA PNEUMOFTIZIOLOGILOR - STUDIU EMPIRIC. Todea, Doina; Rogozea, Liliana; Rosca, Loredana; Herescu, Andreea // Clujul Medical;Mar2011, Vol. 84 Issue 1, p41 

    The article on ethical dilemmas that arise in work in a pneumo-phtisiology hospital aims to address issues of a disease, although no longer seen as a major threat to the health of individuals given the possibility of current treatment, which is, unfortunately, a health problem. Tuberculosis...

  • Trend of Tuberculosis Cases under DOTS Strategy in Dakshina Kannada District Of Karnataka, India: Issues and Challenges. Kumar, S. Ganesh; Kumar, H. N. Harsha; Ramakrishna, Rao; Jayarama, S.; Kotian, M. S. // Iranian Journal of Public Health;2009, Vol. 38 Issue 4, p72 

    Background: Tuberculosis remains a worldwide public health problem and India accounts for highest TB burden in the world. The aim of the study was to evaluate the trend and treatment outcome of tuberculosis (TB) cases treated under DOTS strategy at a district level in Karnataka, India. Methods:...

  • Sputum smear negative pulmonary tuberculosis: sensitivity and specificity of diagnostic algorithm.  // BMC Research Notes;2011, Vol. 4 Issue 1, p475 

    The article presents a study which was conducted in Dar-es-Salaam, Tanzania in order to determine the sensitivity and specificity of the tuberculosis treatment algorithm, recommended by the National Tuberculosis and Leprosy Programme, used for the diagnosis of sputum smear negative pulmonary...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics