TITLE

Topical antibiotics for acute bacterial conjunctivitis: Cochrane systematic review and meta-analysis update

AUTHOR(S)
Sheikh, Aziz; Hurwitz, Brian
PUB. DATE
December 2005
SOURCE
British Journal of General Practice;Dec2005, Vol. 55 Issue 521, p962
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background Uncertainty remains about the extent to which findings from our previously published systematic review and meta-analysis of double-blind, randomised controlled trials of topical antibiotics compared with placebo in the management of patients with acute bacterial conjunctivitis treated in secondary care outpatient settings are generalisable to the management of the condition in primary care settings. We updated our review, undertaking searches, methodological assessment, data extraction and analysis according to a pre-defined protocol. In addition to the previous three included studies, we identified two additional double-blind primary care trials, one which compares fusidic acid gel with placebo gel and one which compares chloramphenicol eye drops with placebo eye drops in children. Meta-analyses of clinical and microbiological remission data reveal that topical antibiotics are of benefit in improving early (days 2-5) clinical (relative risk [RR] = 1.24. 95% confidence interval [CI] = 1.05 to 1.45) and microbiological (RR = 1.77. 95% CI = 1.23 to 2.54) remission rates; later (days 6-10) data reveal that these early advantages in clinical (RR = 1.11, 95% CI = 1.02 to 1.21) and microbiological cure rates are reduced (RR 1,56. 95% CI = 1.17 to 2.09), but persist. Most cases of acute bacterial conjunctivitis resolve spontaneously. While topical antibiotics are associated with significantly improved rates of early (days 2-5) clinical remission, this benefit is marginal for later remission (days 6-10).
ACCESSION #
19888455

 

Related Articles

  • Relationship between plasmid occurrence and antibiotic resistance in Myroides odoratimimus SKS05-GRD isolated from raw chicken meat. Suganthi, Ramasamy; Shanmuga Priya, Thangavel; Saranya, Asokan; Kaleeswaran, Thangaraj // World Journal of Microbiology & Biotechnology;Jun2013, Vol. 29 Issue 6, p983 

    Fifteen flavobacterium strains were isolated from raw chicken meat, raw goat meat and poultry soil in Coimbatore, Tamil Nadu. Most of the isolates developed yellow pigmented colonies with mucoid-spreading edges on food flavobacterium medium. The flavobacteria were Gram-negative rods and failed...

  • Prescribing systemic antibiotics when replanting avulsed teeth. Evans, Dafydd // Evidence-Based Dentistry;Dec2009, Vol. 10 Issue 4, p103 

    Data sourcesFour databases were searched for relevant citations: Ovid Medline, Cochrane Library, PubMed and ISI Web of Science.Study selectionStudies were included if they were conducted on human permanent anterior teeth and they reported systematic antibiotic use and periodontal healing...

  • Does Antibiotic Selection Impact Patient Outcome? Harbarth, Stephan; Vandack Nobre; Pittet, Didier // Clinical Infectious Diseases;1/1/2007, Vol. 44 Issue 1, p87 

    Inadequate antibiotic therapy, generally defined as microbiologically ineffective anti-infective therapy against the causative pathogen, can influence patient outcome. However, the detrimental effects of inadequate antibiotic therapy seem to become weaker in the most severely ill patients with...

  • Linezolid and neuropathy.  // WHO Drug Information;2005, Vol. 19 Issue 1, p22 

    The article informs that linezolid is a synthetic antibacterial agent in a new class of antibiotics, the oxazolidinones, and has been marketed in Canada since 2001. Linezolid is active against methicillinand vancomycin-resistant Gram-positive microorganisms. The safety and efficacy of linezolid...

  • Quantitative structure-activity relationship analysis to elucidate the clearance mechanisms of Tc-99m labeled quinolone antibiotics. Salahinejad, M.; Mirshojaei, S. // Journal of Radioanalytical & Nuclear Chemistry;Jan2016, Vol. 307 Issue 1, p437 

    This study aims to establish molecular modeling methods for predicting the liver and kidney uptakes of Tc-99m labeled quinolone antibiotics. Some three-dimensional quantitative-activity relationships (3D-QSAR) models were developed using comparative molecular field analysis and grid-independent...

  • Antibiotic treatment in vitro of phenotypically tolerant bacterial populations. Camilla Wiuff; Dan I. Andersson // Journal of Antimicrobial Chemotherapy (JAC);Feb2007, Vol. 59 Issue 2, p254 

    Objectives: Most pharmacodynamic models used for design of treatment regimens are based on time–kill data obtained with normal cells in the susceptible state without taking into account the killing kinetics of the antibiotic-tolerant cells in the population. We compared the...

  • Closed-space hand infections: diagnostic and treatment considerations. Rigopoulos, Nikolaos; Dailiana, Zoe H.; Varitimidis, Sokratis; Malizos, Kostantinos N. // Orthopedic Reviews;2012, Vol. 4 Issue 2, p83 

    Despite modern diagnostic methods, surgical advances and antibiotics evolution, acute closed-space hand infections still remain a therapeutic challenge. The aim of this review is to present its special clinical features and the current therapeutic management based on the infection site, the type...

  • Tracking Acquired Antibiotic Resistance in Commensal Bacteria of Galápagos Land Iguanas: No Man, No Resistance. Thaller, Maria Cristina; Migliore, Luciana; Marquez, Cruz; Tapia, Washington; Cedeño, Virna; Rossolini, Gian Maria; Gentile, Gabriele // PLoS ONE;2010, Vol. 5 Issue 2, p1 

    Background: Antibiotic resistance, evolving and spreading among bacterial pathogens, poses a serious threat to human health. Antibiotic use for clinical, veterinary and agricultural practices provides the major selective pressure for emergence and persistence of acquired resistance determinants....

  • Mycoplasma Suppression of THP-1 Cell TLR Responses Is Corrected with Antibiotics. Zakharova, Ekaterina; Grandhi, Jaykumar; Wewers, Mark D.; Gavrilin, Mikhail A. // PLoS ONE;2010, Vol. 5 Issue 3, p1 

    Mycoplasma contamination of cultured cell lines is a serious problem in research, altering cellular response to different stimuli thus compromising experimental results. We found that chronic mycoplasma contamination of THP-1 cells suppresses responses of THP-1 cells to TLR stimuli. For example,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics