TITLE

Expression of Active α-N-Acetylglucosaminidase/TAT Chimerae in Cultured Spodoptera frugiperda Cells

AUTHOR(S)
Bandsmer, Judith C.; Campbell, Tessa N.; Cheyne, Ian; Choy, Francis Y.M.
PUB. DATE
April 2006
SOURCE
Protein & Peptide Letters;Apr2006, Vol. 13 Issue 4, p353
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We examined the production and secretion of fusion constructs containing α-N-acetylglucosaminidase, the enzyme deficient in Sanfilippo B, and either wildtype TAT or modified TAT in cultured Spodoptera frugiperda cells. All constructs exhibited successful expression of active enzyme, suggesting the future possibility of utilizing TAT/α-Nacetylglucosaminidase chimerae in enzyme replacement therapy.
ACCESSION #
19850323

 

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