General considerations

September 2004
WHO Technical Report Series;2004, Issue 927, p66
Academic Journal
The article focuses on polysaccharide vaccines for infections caused by Streptococcus pneumoniae, which are responsible for substantial morbidity and mortality, commonly on children and the elderly. Pneumociccus are classified based on chemical and serological distinct capsular polysaccharides. Polysaccharide vaccines are efficacious in children about 2 year of age but are not effective in younger children, while polysaccharide-protein conjugates have been demonstrated to be high in immunogenic in infants and to stimulate T-cell dependent immunity.


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