High Serum Hepatitis C Virus (HCV) RNA Load Predicts the Presence of HCV RNA in Saliva from Individuals with Chronic and Acute HCV Infection

Wang, Chia C.; Morishima, Chihiro; Minjun Chung; Engelberg, Rebecca; Krantz, Elizabeth; Krows, Meighan; Sullivan, Daniel G.; Gretch, David R.; Corey, Lawrence
March 2006
Journal of Infectious Diseases;3/1/2006, Vol. 193 Issue 5, p672
Academic Journal
The detection of hepatitis C virus (HCV) in saliva was studied. Twenty-three subjects with chronic HCV infection and 1 subject with acute HCV infection were enrolled in a 21-day study. Roche COBAS Amplicor and Bayer VERSANT HCV RNA qualitative assays were used. For the 23 subjects with chronic HCV infection, 72% of 474 saliva samples were positive (or were imputed to be positive) for HCV RNA. Serum HCV RNA load predicted the detection of HCV RNA in saliva (odds ratio of 378.7 [95% confidence interval, 18.9- 9996.6] for each additional log10value). This association was also observed in 1 subject with acute HCV infection. Thus, our data demonstrate that salivary HCV RNA detection was associated with serum HCV RNA load in individuals who were chronically or acutely infected with HCV.


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