TITLE

A Cluster Study of Predictors of Severe West Nile Virus Infection

AUTHOR(S)
Abroug, Fekri; Ouanes-Besbes, Lmviia; Letaief, Mondher; Romdhane, Foued Ben; Khairallah, Moncef; Triki, Henda; Bouzouiaia, Noureddine
PUB. DATE
January 2006
SOURCE
Mayo Clinic Proceedings;Jan2006, Vol. 81 Issue 1, p12
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To assess the value of multifocal chorioretinitis and of clinical manifestations and biologic parameters In the diagnosis of West Nile virus (WNV) Infection. PATIENTS AND METHODS: We conducted a prospective, controlled case series study during an outbreak of WNV infection between August 15 and October 24, 2003, of 64 consecutive patients who presented with clinical manifestations consistent with WNV disease. in each patient, standardized clinical and biologic data were collected. An ophthalmologic examination searching particularly for multifocal chorioretinitis was performed. RESULTS: Of 64 patients who presented primarily with meningitis and/or encephalitis, 36 had 1gM antibodies against WNVI The WNV-Infected patients tended to be older (median age of 54 years vs 46 years in WNV infection and control groups, respectively) and more frequently had diabetes (30% vs 7% in WNV infection and control groups, respectively; P = .03). Multifocal chorioretinitis was found in 75% of WNV-infected patients but in no patient in the control group (P = 001). Blood glucose and amylase levels were higher In WNV-Infected patients, whereas serum sodium levels were lower. The cerebrospinal fluid leukocyte count and protein levels were significantly higher In WNV meningitis or encephalitis. Overall, multifocal chorioretinitis had 100% specificity and 73% sensitivity (88% when only patients with meningitis or encephalitis were analyzed) for the diagnosis of WNV. Multivariate analysis disclosed multifocal chorioretinitis as the only predictor of WNV Infection (odds ratio, 62; 95% confidence interval, 6-700; P = .001). CONCLUSION: Multifocal chorioretinitis appears to be a specific marker of WNV infection, particularly in patients who present with meningoencephalitis. An ophthalmologic examination should be part of the routine evaluation of such patients.
ACCESSION #
19800780

 

Related Articles

  • West Nile virus: the current climate. Prow, Natalie A.; Khromykh, Alexander A.; Hall, Roy A. // MLO: Medical Laboratory Observer;Apr2009, Vol. 41 Issue 4, p10 

    The article focuses on the impact of West Nile virus (WNV), a member of the Japanese encephalitis antigenic complex of flaviviruses, on public health in the U.S. It mentions that the virus has rapidly spread across North America and Argentina and maintains in nature via a mosquito-bird-mosquito...

  • Too Important to Forget. Ostroff, Stephen M. // JAMA: Journal of the American Medical Association;7/17/2013, Vol. 310 Issue 3, p267 

    The article offers information related to the West Nile virus, mosquito-transmitted virus that appeared in Queens, New York, late in the summer of 1999. It informs that the virus spread across North America to the Pacific coast in 5 years. It discusses the complications and human health risks...

  • Economic Cost Analysis of West Nile Virus Outbreak, Sacramento County, California, USA, 2005. Barber, Loren M.; Schleier III, Jerome J.; Peterson, Robert K. D. // Emerging Infectious Diseases;Mar2010, Vol. 16 Issue 3, p480 

    In 2005, an outbreak of West Nile virus (WNV) disease occurred in Sacramento County, California; 163 human cases were reported. In response to WNV surveillance indicating increased WNV activity, the Sacramento-Yolo Mosquito and Vector Control District conducted an emergency aerial spray. We...

  • Linear pattern of West Nile virus-associated chorioretinitis is related to retinal nerve fibres organization. Khairallah, M.; Ben Yahia, S.; Attia, S.; Zaouali, S.; Ladjimi, A.; Messaoud, R. // Eye;Jul2007, Vol. 21 Issue 7, p952 

    PurposeTo clarify the reason for the linear pattern of West Nile virus (WNV)-associated chorioretinitis.MethodsThe study included 12 patients (24 eyes) with WNV-associated chorioretinitis. All the patients underwent a complete ophthalmic evaluation, including dilated fundus examination, fundus...

  • The rash of West Nile virus infection. Gorsche, Ronald; Tilley, Peter // CMAJ: Canadian Medical Association Journal;5/24/2005, Vol. 172 Issue 11, p1440 

    Presents a case report of a West Nile virus infection rash. Symptoms experienced by the patient; Incidence of West Nile virus infection in Canada; Description of rashes associated with the infection.

  • Problem Solved? West Nile Virus and Transfusion Safety. Petersen, Lyle R.; Epstein, Jay S. // New England Journal of Medicine;8/4/2005, Vol. 353 Issue 5, p516 

    Presents an editorial about the West Nile virus and the safety of blood transfusions. Details of two reports in this issue by Stramer and Butsch; How both reports confirm that the viremia associated with West Nile virus infection is of low titer and borders on the lower limit of sensitivity of...

  • West Nile Virus Drug Discovery. Siew Pheng Lim; Pei-Yong Shi // Viruses (1999-4915);Dec2013, Vol. 5 Issue 12, p2977 

    The outbreak of West Nile virus (WNV) in 1999 in the USA, and its continued spread throughout the Americas, parts of Europe, the Middle East and Africa, underscored the need for WNV antiviral development. Here, we review the current status of WNV drug discovery. A number of approaches have been...

  • The Effect of West Nile Virus Perceptions and Knowledge on Protective Behavior and Mosquito Breeding in Residential Yards in Upstate New York. Tuiten, Wieteke; Koenraadt, Constantianus J. M.; McComas, Katherine; Harrington, Laura C. // EcoHealth;Mar2009, Vol. 6 Issue 1, p42 

    A knowledge, attitudes, and practices (KAP) questionnaire combined with entomological surveys of residential mosquito-breeding sites were conducted in two Upstate New York neighborhoods. We tested the hypothesis that “correct” West Nile virus (WNV) knowledge and perceptions...

  • West Nile virus transmission in resident birds, Dominican Republic. Komar, Oliver; Robbins, Mark B.; Klenk, Kaci; Blitvich, Bradley J.; Marlenee, Nicole L.; Burkhalter, Kristen L.; Gubler, Duane J.; Gonzalvez, Guillermo; Pena, Carlos J.; Peterson, A. Townsend; Komar, Nicholas; Gonzálvez, Guillermo; Peña, Carlos J // Emerging Infectious Diseases;Oct2003, Vol. 9 Issue 10, p1299 

    We report West Nile virus (WNV) activity in the Dominican Republic for the first time. Specific anti-WNV antibodies were detected in 5 (15%) of 33 resident birds sampled at one location in November 2002. One seropositive bird was <4 months old, indicating a recent infection.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics