TITLE

Asthma exacerbations during pregnancy: incidence and association with adverse pregnancy outcomes

AUTHOR(S)
Murphy, V. E.; Clifton, V. I.; Gibson, P. G.
PUB. DATE
February 2006
SOURCE
Thorax;Feb2006, Vol. 61 Issue 2, p169
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Exacerbations of asthma during pregnancy represent a significant clinical problem and may be related to poor pregnancy outcomes. A systematic review of the literature was conducted for publications related to exacerbations during pregnancy. Four studies with a control group (no asthma) and two groups of women with asthma (exacerbation, no exacerbation) were included in meta-analyses using fixed effects models. During pregnancy, exacerbations of asthma which require medical intervention occur in about 20% of women, with approximately 6% of women being admitted to hospital. Exacerbations during pregnancy occur primarily in the late second trimester; the major triggers are viral infection and non-adherence to inhaled corticosteroid medication. Women who have a severe exacerbation during pregnancy are at a significantly increased risk of having a low birth weight baby compared with women without asthma. No significant associations between exacerbations during pregnancy and preterm delivery or pre-eclampsia were identified. Inhaled corticosteroid use may reduce the risk of exacerbations during pregnancy. Pregnant women may be less likely to receive oral steroids for the emergency management of asthma. The effective management and prevention of asthma exacerbations during pregnancy is important for the health of both the mother and fetus.
ACCESSION #
19787755

 

Related Articles

  • Asthma: clinical assessment.  // Thorax;Dec2004 Supplement, Vol. 59, p50 

    The article presents some papers related to clinical assessment of asthma. There is currently great interest in developing non-invasive measures of airway inflammation in asthma. Proposed markers of airway inflammation and or oxidative stress in asthma include the exhaled gases, nitric oxide...

  • Treatment Comparison of Budesonide/ Formoterol with Salmeterol/Fluticasone Propionate in Adults Aged ≥16 Years with Asthma: Post Hoc Analysis of a Randomized, Double-Blind Study. Kuna, Piotr // Clinical Drug Investigation;2010, Vol. 30 Issue 9, p565 

    Background: Three fixed maintenance-dose inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) combinations for the treatment of asthma are currently available: salmeterol/fluticasone propionate (Seretide™/Advair™/ Adoair™) budesonide/formoterol (Symbicort®) and...

  • Biopharmaceutical Therapeutics for Asthma Remodeling. Das, A. M.; Griswold, D. E.; Torphy, T. J.; Li, L. // Current Pharmaceutical Design;Sep2006, Vol. 12 Issue 25, p3233 

    Current asthma therapy is aimed at controlling disease symptoms. A subset of asthma patients remains symptomatic despite optimal therapy indicating that an unmet medical need exists for these patients. Innovative therapeutics are needed to treat the unmet need in asthma and biopharmaceutical...

  • Mild persistent asthma and inhaled corticosteroids: is daily therapy really necessary? Bauchner, Howard // Archives of Disease in Childhood;Oct2005, Vol. 90 Issue 10, p1094 

    This article cites a study on the treatment of mild persistent asthma, which was published in the May 6, 2005 issue of the "Journal Watch Pediatrics and Adolescent Medicine." In this double-blind trial, researchers randomized 225 adults with mild persistent asthma to receive twice-daily inhaled...

  • APRECIERI ASUPRA EFECTELOR ADVERSE ALE CORTICOSTEROIZILOR INHALATORI ADMINISTRAÅ¢I ÃŽN DOZE MICI LA COPIII ASTMATICI. MOHOR, C. // Acta Medica Transilvanica;dec2012, Vol. 17 Issue 4, p103 

    The way in which inhaled corticosteroids influence the growth and the development of the children with asthma is relatively little studied, the results being often contradictory. The study was conducted on two hundred subjects with one hundred children with asthma treated with inhaled...

  • Magnesium and Outcomes in Children with Acute Asthma. Sadovsky, Richard // American Family Physician;6/15/2001, Vol. 63 Issue 12, p2441 

    Presents information on a study by R.J. Scarfone and others that studied the early administration of magnesium to moderately to severely ill children with asthma in a randomized, double-blind, placebo-controlled clinical trial. Description of the study and its results; Conclusion that among a...

  • COMMENTARY: Adults who require inhaled corticosteroids benefits from a moderate starting dose. Thien, Frank // ACP Journal Club;Nov/Dec2004, Vol. 141 Issue 3, p72 

    iThe article presents a commentary on the study, which concluded that adults who require inhaled corticosteroids benefits from a moderate starting dose. Airway inflammation is the key pathologic feature of asthma, and ICSs remain the most effective anti-inflammatory medication and the...

  • Daily corticosteroids were not better than as-needed corticosteroids in mild persistent asthma.  // ACP Journal Club;Nov/Dec2005, Vol. 143 Issue 3, p60 

    This article presents information on a clinical study according to which daily corticosteroids were not better than as-needed corticosteroids in mild persistent asthma. This study explored that in patients with mild persistent asthma, how does intermittent, short-course corticosteroid treatment...

  • Breathing life into asthma research. Sayburn, Anna // Update;5/19/2005, Vol. 70 Issue 5, p5 

    This article discusses about the papers on asthma. After years in which little seemed to change, the past month has seen two new research papers that offer different ways of thinking about the disease. It has been accepted in the Great Britain that regular use of inhaled corticosteroids is the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics