TITLE

Radical Resection in Signet Ring Carcinoma of the Ampulla of Vater: Report of an 11-Year Survivor

AUTHOR(S)
Bloomston, Mark; Walker, Michael; Frankel, Wendy L.
PUB. DATE
February 2006
SOURCE
American Surgeon;Feb2006, Vol. 72 Issue 2, p193
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Carcinomas of the ampulla of Vater are uncommon tumors but have a better prognosis than typical pancreatic cancers. They tend to be well or moderately differentiated while the poorly differentiated variants are still quite aggressive. Signet ring features associated with poor differentiation traditionally confer a dismal prognosis in other gastrointestinal malignancies, particularly gastric cancer. Signet cell ring morphology has only been described in a few ampullary carcinomas with all cases reporting short follow-up. We describe a 58-year-old woman who presented with painless jaundice and a prominent ampulla of Vater by endoscopy. She underwent pancreaticoduodenectomy and was found to have a 1.0 x 0.8 cm poorly differentiated carcinoma with prominent signet ring cell features arising from the ampulla of Vater and invading into the periampullary duodenum but sparing the pancreatic parenchyma. No distant or nodal metastases were seen (pT2N0M0). No adjuvant therapy was given, and the patient remains free of disease with 134 months of follow-up.
ACCESSION #
19750315

 

Related Articles

  • Squamous Differentiation in High Grade Large Cell Neuroendocrine Carcinoma of Ampulla of Vater. Gulwani, Hanni; Roy, Subimal; Chopra, P. // Internet Journal of Pediatrics & Neonatology;2008, Vol. 7 Issue 1, p15 

    Neuroendocrine tumors constitute a spectrum of lesions with varied morphology and clinical behavior. High grade neuroendocrine carcinoma includes both small cell and large cell neuroendocrine carcinoma (LCNEC). LCNEC in ampullary region is rare with only few cases reported in literature....

  • Squamous Differentiation in High Grade Large Cell Neuroendocrine Carcinoma of Ampulla of Vater. Gulwani, Hanni; Roy, Subimal; Chopra, P. // Internet Journal of Pathology;2008, Vol. 7 Issue 1, p15 

    Neuroendocrine tumors constitute a spectrum of lesions with varied morphology and clinical behavior. High grade neuroendocrine carcinoma includes both small cell and large cell neuroendocrine carcinoma (LCNEC). LCNEC in ampullary region is rare with only few cases reported in literature....

  • Jaundice at Presentation Heralds Advanced Disease and Poor Prognosis in Patients with Ampullary Carcinoma. Yokoyama, Naoyuki; Shirai, Yoshi; Wakai, Toshifuni; Nagakurav, Shigenori; Akazawa, Kohei; Hatakeyama, Katsuyoshi // World Journal of Surgery;Apr2005, Vol. 29 Issue 4, p519 

    Jaundice is a common manifestation of ampullary carcinoma. The aim of this study was to evaluate the correlation between jaundice at initial presentation and the degree of tumor spread and to determine the prognostic significance of jaundice in patients with ampullary carcinoma. Fifty-nine...

  • P-0160PREDICTING SURVIVAL IN ADENOCARCINOMAS OF THE AMPULLA OF VATER: RETROSPECTIVE ANALYSIS OF A SINGLE-CENTER EXPERIENCE. Martinez-Galán, Joaquina; Soberino-García, Jesús; González-Rivas, Cynthia; Ruiz-Vozmediano, Julia; Castillo-Portellano, Lucia; Conde-Herrero, Verónica; García-García, Javier; González-Astorga, Beatriz; Pérez, Juan Ramón Delgado // Annals of Oncology;Jun2013, Vol. 24 Issue suppl_4, piv81 

    No abstract available.

  • Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. Westgaard, Arne; Tafjord, Svetlana; Farstad, Inger N.; Cvancarova, Milada; Eide, Tor J.; Mathisen, Oystein; Clausen, Ole Petter F.; Gladhaug, Ivar P. // BMC Cancer;2008, Vol. 8, Special section p1 

    Background: Resectable adenocarcinomas in the pancreatic head, by definition "periampullary", originate from ampullary, duodenal, biliary, or ductal pancreatic epithelium. Typically, periampullary adenocarcinomas have either intestinal or pancreatobiliary type of differentiation, and the type of...

  • Technical aspects of performing transduodenal ampullectomy. Maithel, Shishir K.; Fon, Yuman; Fong, Yuman // Journal of Gastrointestinal Surgery;Sep2008, Vol. 12 Issue 9, p1582 

    Transduodenal ampullectomy is a procedure that can be used to remove either benign or malignant tumors arising from the ampulla of Vater. Specific indications for performing this procedure remain controversial. In this report, we describe the technical details necessary for successfully...

  • Malignant gastrointestinal stromal tumor of the ampulla of Vater presenting with obstructive jaundice. Fillippou, D.; Pashalldis, N.; Skandalakis, P.; Rizos, S. // Journal of Postgraduate Medicine;Jul-Sep2006, Vol. 52 Issue 3, p204 

    Malignant gastrointestinal stromal tumor (GIST) consists a rare neoplasm, developing in small intestine and stomach. The presenting manifastations include weakness, weight loss, nausea, melena and anaemia. The present case refers to a 65 years old female patient with a GIST of the ampulla of...

  • Local Excision of Intraductal Papillary Mucinous Neoplasm of the Papilla of Vater. SEZER, Atakan; Coskun, Irfan; USTA, Ufuk // Internet Journal of Surgery;2010, Vol. 22 Issue 2, p1 

    Tumors of the ampulla of Vater are rare histopathological conditions. These tumors vary between 0.063 and 0.21% on autopsy investigations but the frequency of their diagnosis is increasing because of the extensive use of flexible endoscopy. A 55-year-old man presented with a history of abdominal...

  • Treatment of Ampullary Villous Adenomas That May Harbor Carcinoma Jordan Jr., Paul H.; Ayala, Gustavo; Rosenberg, Wade R.; Kinner, Beatriz M.; Jordan, Paul H Jr // Journal of Gastrointestinal Surgery;Sep2002, Vol. 6 Issue 5, p770 

    Villous adenoma of the ampulla of Vater is a rare tumor. It is a deceptive tumor because it is a premalignant lesion and biopsies of the lesion are false negative in 25% to 56% of patients. The primary focus of this report is 23 of 30 patients with villous adenoma of the ampulla of Vater who...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics