Oral Clefts With Associated Anomalies: Methodological Issues

Wyszynski, Diego F.; Sárközi, Andrea; Czeizel, Andrew E.
January 2006
Cleft Palate-Craniofacial Journal;Jan2006, Vol. 43 Issue 1, p1
Academic Journal
Objective: To discuss methodological factors that account for the wide variation in the reported prevalence rates of anomalies associated with oral clefts. Conclusions: The published prevalences of associated anomalies vary considerably because of the following: (1) differences in case definition and inclusion/exclusion criteria; (2) length of time after birth that cases are examined; (3) variability of clinical expression of associated anomalies; (4) knowledge and technology available to produce syndrome delineation; (5) selection of patients, sources of ascertainment, and sample size; and (6) true population differences and changes in frequency over time.


Related Articles

  • A Rare Craniofacial Cleft: Numbers 7, 2, and 3 Clefts Accompanied by a Single Median Lip Pit. Sigler, Michael Orlin; Stein, John; Zuker, Ronald // Cleft Palate-Craniofacial Journal;May2004, Vol. 41 Issue 3, p327 

    Objective: A unique case of a unilateral partial Tessier no. 7 cleft accompanied by no. 2 and 3 clefts along with a single median lip pit is presented. The history, genetics, epidemiology, classifications, embryology, pathogenesis, and correction techniques are briefly reviewed. After an...

  • TGFB3 displays parent-of-origin effects among central Europeans with nonsyndromic cleft lip and palate. Reutter, Heiko; Birnbaum, Stefanie; Mende, Meinhard; Lauster, Carola; Schmidt, Gül; Henschke, Henning; Saffar, Mitra; Martini, Markus; Lauster, Roland; Schiefke, Franziska; Reich, Rudolf; Braumann, Bert; Scheer, Martin; Knapp, Michael; Nöthen, Markus; Kramer, Franz-Josef; Mangold, Elisabeth // Journal of Human Genetics;Jul2008, Vol. 53 Issue 7, p656 

    Mice with a deletion of Tgf-β3 (−/−) and association studies in humans of different ethnicities support the involvement of TGFB3 in the etiology of orofacial clefts. In this study, we investigated the relevance of TGFB3 in the development of cleft lip and palate (CL/P) among 204...

  • Craniofacial Morphology of Dutch Patients With Bilateral Cleft Lip and Palate and Noncleft Controls at the Age of 15 Years. van den Dungen, Geer M.; Ongkosuwito, Edwin M.; Aartman, Irene H. A.; Prahl-Andersen, Birte // Cleft Palate-Craniofacial Journal;Nov2008, Vol. 45 Issue 6, p661 

    Objective: Comparison of craniofacial morphology in bilateral cleft lip and palate patients to that of a noncleft control group at the age of 15 years. Design: A cross-sectional study of cephalometric data. Subjects and Methods: Cephalometric records of 41 consecutive patients (32 boys and 9...

  • Interferon regulatory factor-6: a gene predisposing to isolated cleft lip with or without cleft palate in the Belgian population. Ghassibé, Michella; Bayet, Benedicte; Revencu, Nicole; Verellen-Dumoulin, Christine; Gillerot, Yves; Vanwijck, Romain; Vikkula, Miikka // European Journal of Human Genetics;Nov2005, Vol. 13 Issue 11, p1239 

    Cleft lip with or without cleft palate is the most frequent craniofacial malformation in humans (∼1/700). Its etiology is multifactorial; some are a result of a genetic mutation, while others may be due to environmental factors, with genetic predisposition playing an important role. The...

  • Registry- and Clinic-Based Analyses of Birth Defects and Syndromes Associated With Cleft Lip/Palate in Victoria, Australia. Tiong Yang Tan; Amor, David J.; Riley, Merilyn; Halliday, Jane; Kilpatrick, Nicky; Simms, Katrina; White, Susan M. // Cleft Palate-Craniofacial Journal;Nov2009, Vol. 46 Issue 6, p583 

    Objective: To study the birth defects and syndromes associated with cleft lip and/or cleft palate in children born from 2000 through 2002 in Victoria, Australia, comparing data from the birth defects registry and detailed clinical assessment. Design, Setting, and Participants: Data recorded in...

  • Rotation-Transposition Correction of Nasal Deformity in Tessier Number 1 and 2 Clefts. Rashid, Mamoon; ul Islam, Muhammad Zia; Tamimy, Muhammad Sarmad; ul Haq, Ehtesham; Aman, Samina // Cleft Palate-Craniofacial Journal;Nov2009, Vol. 46 Issue 6, p674 

    Objective: To formulate a standardized procedure for repair of the nasal component of Tessier number 1 and 2 clefts. Patients and Methods: The procedure was performed from 1998 to 2007 in 13 patients with congenital nasal clefts of different degrees of expression corresponding to Tessier 1 and...

  • Cleft Lip; Cleft Palate.  // Diseases & Disorders: A Nursing Therapeutics Manual, 2nd edition;2002, p257 

    Provides information on the facial malformations called cleft lip and cleft palate. Causes; Assessment and diagnosis; Treatment.

  • Syndromes Associated with Facial Clefting. GORLIN, ROBERT J. // Journal of Dental Research;Nov1968, Vol. 47 Issue 6, p935 

    This article reports on the syndromes associated with cleft lips and cleft palates. The article discusses popliteal pterygium syndrome, syndactyly and eclodactyly anomolies, talipes equinovarus, and orofacial-digital syndrome. Information is also provided on how dominant traits affect...

  • Cleft Palate Patients–The Social Work Approach. Starr, Philip; Zirpoli, Edith // Health & Social Work;May1979, Vol. 4 Issue 2, p104 

    From birth to maturity, the needs of cleft lip and cleft palate patients change. For such patients, fixed teams of specialists headed by a surgeon may not be the best answer. The authors outline the clinical characteristics of both deformities and show how social workers are uniquely equipped to...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics