Synthesis of β-Amino Alcohols by Regioselective Ring Opening of Epoxides with Aromatic Amines Catalyzed by Tin (II) Chloride [1]

Alam, M. Mujahid; Varala, Ravi; Enugala, Ramu; Adapa, Srinivas R.
March 2006
Letters in Organic Chemistry;Mar2006, Vol. 3 Issue 3, p187
Academic Journal
Tin (II) chloride dihydrate catalyses the nucleophilic ring opening of epoxide by aromatic amines leading to an efficient synthesis of β-amino alcohols in very good yields. The reactions are completely antistereoselective, highly regioselctive and proceed at ambient temperature which make this procedure particularly an alternative strategy for the synthesis of β-amino alcohols.


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