SOME CANCERS ARE STEM CELL DISEASES
Tags: STEM cells; CANCER; CANCER -- Treatment; BONE marrow cells; MUTATION (Biology); CELL division
Related Articles
- The hunt for cancer-initiating cells: a history stemming from leukemia. Buzzeo, M. P.; Scott, E. W.; Cogle, C. R. // Leukemia (08876924);Aug2007, Vol. 21 Issue 8, p1619
Conventional cancer therapies are plagued by disease relapses due to incomplete eradication of cancer-initiating cells. Evidence for cancer-initiating cells originally arose from studies in hematology and leukemia. Lessons learned from hematopoietic stem cells laid the bedrock for understanding...
- Implanted Device Captures Stem Cells From Blood Stream In Live Rats. // Bioscience Technology;Mar2008, Vol. 33 Issue 3, p14
The article discusses research being done on capturing adult stem cells from the blood stream of live rats. It references a study by CellTraffix researchers published in the "British Journal of Haematology." The researchers used an implanted device to capture seven times more hematopoietic stem...
- 731. Hematopoietic Stem Cell Gene Transfer and Integration Site Analysis in Tumor-Prone Mice Uncovers Low Genotoxicity of Lentiviral Vector Integration. Montini, Eugenio; Cesana, Daniela; Schmidt, Manfred; Sanvito, Francesca; Ponzoni, Maurilio; Sergi, Lucia Sergi; Benedicenti, Fabrizio; Bartholomae, Cynthia; Di Serio, Clelia; Doglioni, Claudio; von Kalle, Christof; Naldini, Luigi // Molecular Therapy;Jun2006, Vol. 13, pS282
Insertional mutagenesis represents a major hurdle to successful gene therapy and mandates for sensitive pre-clinical assays of genotoxicity. Cdkn2a-/- mice are defective for p53 and Rb pathways, and are susceptible to a broad range of cancer-triggering genetic lesions. We exploited the...
- Allogeneic stem cell transplantation for the treatment of advanced solid tumors. Bregni, Marco; Bernardi, Massimo; Ciceri, Fabio; Peccatori, Jacopo // Springer Seminars in Immunopathology;Sep2004, Vol. 26 Issue 1/2, p95
Allogeneic stem cell transplantation has emerged as a potentially curative treatment modality for patients with hematological malignancies. The graft-versus-leukemia effect, an immune mechanism mediated by the donor immune system, is an important component of the therapeutic effect of allogeneic...
- Stem cells as vectors for antitumour therapy. Loebinger, Michael R.; Janes, Sam M. // Thorax;Apr2010, Vol. 65 Issue 4, p362
Recent research suggests that mesenchymal stem cells (MSCs) are able to migrate specifically to tumours and their metastases throughout the body. This has led to considerable excitement about the possibility of modifying these cells to express anticancer molecules and using them as specific...
- Blood Cancer Update. // PharmaWatch: Cancer;Sep2005, Vol. 4 Issue 9, p16
The article presents news briefs related to developments in the field of blood cancer treatment. Investigators from the University's School of Medicine have found that a protein called NF-Ya activates several genes known to regulate the development of hematopoietic stem cells or blood-producing...
- Hematopoietic Stem-Cell Transplantation. Copelan, Edward A. // New England Journal of Medicine;4/27/2006, Vol. 354 Issue 17, p1813
The article summarizes information surrounding hematopoietic stem cell transplantation and discusses the recent progress in the role of this procedure as far as treating malignant and nonmalignant conditions. The primary use for hematopoietic stem cell transplantations are hematologic and...
- Genomic instability in haematopoietic cells of F1 generation mice of irradiated male parents. Luke, Garry A.; Riches, Andrew C.; Bryant, Peter E. // Mutagenesis;May1997, Vol. 12 Issue 3, p147
Preconceptional paternal irradiation has been implicated as a causal factor in childhood cancer and it has been suggested that this exposure to radiation may play a role in the occurrence of childhood leukaemia clusters in the vicinity of nuclear installations. Using a transgenic mouse system...
- Conditional Neutrality as a Method of Controlling Tumour Growth. Smith, Phillip // Biology Forum / Rivista di Biologia;2005, Vol. 98 Issue 2, p297
Tumours are comprised of populations of mutant cells that are undergoing rapid cell division. The high mutation rate and rapid cell growth results in rapid evolution of the phenotypes required for tumour growth. Short cell cycles, angiogenesis, chemotherapy resistance and metastasis quickly...
