TITLE

The indirect role of site distribution in high-grade dysplasia in adenomatous colorectal polyps

AUTHOR(S)
Khatibzadeh, N.; Ziaee, S. A.; Rahbar, N.; Molanie, S.; Arefian, L.; Fanaie, S. A.
PUB. DATE
October 2005
SOURCE
Journal of Cancer Research & Therapeutics;Oct-Dec2005, Vol. 1 Issue 4, p204
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The appropriate application of Endoscopic modalities for polypectomy depends on the likelihood that the adenoma in question harbors invasive cancer. While prior studies have evaluated polyp size and morphology in assessing the risk of malignancy, in recent decay some authorities have paid more attention to dysplasia. All in all, the relative risk of cancer based on polyp distribution in correlation with dysplasia has not been statistically studied which is done in our study. Methods and Materials: Between June 2001 and March 2004, the distribution of 130 adenomatous polyps was compared with synchronous invasive or in situ cancer. Factors such as Patient age, Patients gender, location of lesion, size of polyp, histological subtype of adenoma on biopsy, degree of dysplasia, synchronous cancer, color of polyp, and number of polyps were included in the data collection. Results: Multivariate logistic regression test was used to evaluate the association between malignancy and various clinical variables. It revealed histological subtype, high grade of dysplasia and size to be independent predictor of malignancy. However; left-sided location and histological subtype to be independent risk factor for high-grade dysplasia. Conclusion: Lesions greater than 1 cm in diameter with high-grade dysplasia after speleinc flexure should be managed as presumptive malignancies with segmental colon resection. In intermediate-risk lesions the physician should decide individually.
ACCESSION #
19637500

 

Related Articles

  • Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas. De Chiara, Loretta; Rodríguez-Piñeiro, Ana M.; Rodríguez-Berrocal, Francisco J.; Cordero, Oscar J.; Martínez-Ares, David; de la Cadena, María Páez // BMC Cancer;2010, Vol. 10, p333 

    Background: Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis. Therefore we aimed to estimate the utility of the sCD26 as a biomarker for CRC and advanced adenomas in a...

  • Clinical significance of distal colon polyps for the prediction of an advanced proximal neoplasm: the KASID prospective multicenter study. Mun Su Kang; Dong Il Park; Yoon Tae Jeen; Bora Keum; Jai Hyun Choi; Sung-Ae Jung; Hyun Soo Kim; Young-Ho Kim; Won Ho Kim; Tae Il Kim; Hyo Jung Kim; Suk Kyun Yang; Seung Jae Myung; Jeong Sik Byeon; Moon Sung Lee; Il Kwon Jung; Moon Kwon Chung; Hwang Choi; Dong Soo Han; Jae Suk Song // International Journal of Colorectal Disease;Feb2008, Vol. 23 Issue 2, p171 

    The possibility of proximal lesion without distal polyps is a weak point of sigmoidoscopic colon cancer screening, but the clinical significance of distal findings for advanced proximal neoplasm (APN) is uncertain. The aim of this study was to assess the significance of a distal finding as a...

  • SELF ASSESSMENT ANSWER: Hyperplastic polyposis coli associated with dysplasia.  // Postgraduate Medical Journal;Aug2001, Vol. 77 Issue 910, p541 

    This article presents questions and answers on the case study of a hyperplastic polyposis coli associated with dysplasia. The most important differential diagnosis to consider in a young patient with multiple colorectal polyps is that of familial adenomatous polyposis. Regular colonoscopy with...

  • A BALANCING VIEW: Pathologist–Clinician Interaction Is Essential. Odze, Robert // American Journal of Gastroenterology;Jun2008, Vol. 103 Issue 6, p1331 

    The article presents the author's views on gastrointestinal pathologists' interaction being essential in colorectal cancer. He states that they have difficulty in agreeing on the presence and degree of dysplasia and wonders if they can be confident on the results of the studies when the initial...

  • Gastric hyperplastic polyps: a review. Jain, Richa; Chetty, Runjan // Digestive Diseases & Sciences;Sep2009, Vol. 54 Issue 9, p1839 

    Hyperplastic polyps represent the commonest polyp encountered in the stomach. They occur in patients of either gender and are commoner in the seventh decade of life. They are usually asymptomatic, small (less than 1 cm in diameter), solitary lesions occurring in the antrum but can present with...

  • Variation in the Detection of Serrated Polyps in an Average Risk Colorectal Cancer Screening Cohort. Hetzel, Jeremy T.; Huang, Christopher S.; Coukos, Jennifer A.; Omstead, Kelsey; Cerda, Sandra R.; Yang, Shi; O'Brien, Michael J.; Farraye, Francis A. // American Journal of Gastroenterology;Dec2010, Vol. 105 Issue 12, p2656 

    OBJECTIVES:Serrated polyps are precursors in an alternative pathway to colon cancer. These polyps are frequently sessile or flat, located in the proximal colon, and may be overlooked during colonoscopy. Histological criteria to classify these polyps have only recently been described. This study...

  • Retrieval of colorectal polyps following snare polypectomy: experience of the multiple-suction technique in 602 cases. Feng Ye; Yanxia Feng; Jianjiang Lin // International Journal of Colorectal Disease;Apr2008, Vol. 23 Issue 4, p431 

    Retrieving colorectal polyp after endoscopic snare polypectomy is time consuming and possibly incurs a failure. The aim of the study was to assess the effectiveness of the multiple-suction (M-S) technique for retrieving a variety of polyps. Four hundred and nine cases received endoscopic snare...

  • Risk Factors for Incomplete Polyp Resection during Colonoscopic Polypectomy. Sang Pyo Lee; In-Kyung Sung; Jeong Hwan Kim; Sun-Young Lee; Hyung Seok Park; Chan Sup Shim // Gut & Liver;Jan2015, Vol. 9 Issue 1, p66 

    Background/Aims: Colonoscopic polypectomy is highly efficient in preventing colorectal cancer, but polyps may not always be completely removed. Improved knowledge of the risk factors for incomplete polyp resection after polypectomy may decrease the cancer risk and additional costs. The aim of...

  • Polyposis coli and the stomach.  // British Medical Journal;10/16/1976, Vol. 2 Issue 6041, p900 

    Focuses on the contribution of the study of gastrointestinal polyposis to the knowledge of the pathogenesis of colorectal cancer. Rarity of the polyps of the small bowel and gastric adenomas; Suggestions for the physician and surgeon for investigating the upper gastrointestinal tract; Absence...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics