Is thiopurine therapy in ulcerative colitis as effective as in Crohn's disease?

Ghosh, S.; Chaudhary, R.; Carpani, M.; Playford, R. J.
January 2006
Gut;Jan2006, Vol. 55 Issue 1, p6
Academic Journal
The article focuses on the question of effectiveness of thiopurine therapy in curing ulcerative colitis (UC). Thiopurine therapy is effective in curing Crohn's disease. But whether it is effective in curing UC or not, is the question of concern. Clinical trials of azathioprine have shown that it is effective in curing Crohn's disease patients who are steroid dependent or resistant. But it is not sure that the use of immunomodulator therapy in UC will give the same results as in the case of Crohn's disease or not. The reason behind this is that the clinical trials conducted to find out the effectiveness of thiopurine therapy in curing UC were scanty, small in size and conflicting in results.


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