TITLE

EVALUATION OF THE TERATOGENICITY OF AQUEOUS EXTRACT OF Labisia pumila var. alata IN RATS

AUTHOR(S)
Wan Ezumi Mohd Fuad; Siti Amrah Sulaiman; Mohamad Nazrul Islam; Mohd Suhaimi Abdul Wahab; Syed Mohsin Sahil Jamalullail
PUB. DATE
July 2005
SOURCE
Malaysian Journal of Medical Sciences;Jul2005, Vol. 12 Issue 2, p13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A dose range study to assess the teratogenic potential of aqueous extract of Labisia pumila var. alata (Kacip Fatimah) was conducted in rodents. The extract at doses of 0 (control), 2, 20, 200, 400, 1000 mg/kg/day were respectively administered by gavaging to 6 groups of pregnant Sprague Dawley rats from day 6 through day 16 of pregnancy and sacrificed on day 21. No significant agent-related effects including changes in maternal body weight (MBW) nor weight gain were observed. The corrected maternal body weights (CMBW) were slightly higher in animals receiving low dose extracts (2 mg/kg/day) as compared to all groups of animals. However, body weight differences were not statistically significant. Gravid uterine weight, number of corpora lutea, number of implantation sites, percentage of foetal resorptions, number of life foetuses, foetal weight and foetal sex ratio showed no significant differences among all group animals. None of the foetuses from all dams showed evidence of external congenital malformations. These findings may suggest that aqueous extracts of Labisia pumila var. alata up to 1000 mg/kg/day statistically do not show any significant teratogenic effects in rats but do affect the maternal body weight and this is dose dependent.
ACCESSION #
19611641

 

Related Articles

  • Teratologic evaluation of p-Dichlorobenzene in the rat. Giavini, E.; Broccia, M.; Prati, M.; Vismara, C. // Bulletin of Environmental Contamination & Toxicology;Dec1986, Vol. 37 Issue 1, p164 

    The article presents a study which aims to assess the teratogenic potential of p-Dichlorobenzene (p-DCB) in rats. The study used 15 rats, with a ratio of one male per two females, in which they were allowed to mate, and pregnant rats were caged individually and fed with 99% pure p-DCB dissolved...

  • Teratogenic effects of caffeine and clomipramine on rat fetus. Takzare, Nasrin; Nikoui, Vahid; Ostadhadi, Sattar; Nabavi, Seyyed Mohammad-Ali; Bakhtiarian, Azam // Tehran University Medical Journal;Sep2012, Vol. 70 Issue 6, p335 

    Background: Obsessive-compulsive disorders and depression have a high prevalence during pregnancy; therefore, pregnant women may take clomipramine and also take other drugs or consume foods that contain caffeine. As investigations about the teratogenic effects of clomipramine and its concurrent...

  • High Dose Zolpidem Induced Fetal Neural Tube Defects. Sharma, Avinash; Sayeed, Neha; Khess, Christoday R. J.; Akhtar, Sayeed // Current Drug Safety;Apr2011, Vol. 6 Issue 2, p128 

    Use of zolpidem, a short-acting imidazopyridine hypnotic, has not been associated with teratogenic effects in usual clinical doses. We report a case of fetal neural tube defects occurring in a female dependent on zolpidem and consuming high doses in the first trimester of pregnancy. Possible...

  • Identifying Major Congenital Malformations in the UK General Practice Research Database (GPRD). Charlton, Rachel A.; Weil, John G.; Cunnington, Marianne C.; de Vries, Corinne S. // Drug Safety;2010, Vol. 33 Issue 9, p741 

    Background: Postmarketing teratogen surveillance is essential and requires a data source that can reliably capture a wide range of congenital malformations. The UK General Practice Research Database (GPRD) may have the potential to be used for this kind of surveillance. Objective: To assess the...

  • Is the use of letrozole to induce ovulation teratogenic? Kaur Gill, Simerpal; Moretti, Myla; Koren, Gideon // Canadian Family Physician;Mar2008, Vol. 54 Issue 3, p353 

    QUESTION A patient of mine has been prescribed letrozole to induce ovulation; however, a recent release from the Food and Drug Administration contraindicates the use of letrozole in premenopausal women owing to teratogenicity. Does the use of letrozole increase the risk of a child being born...

  • Evaluation of Enamel Matrix Derivative (EMD) Teratogenicity on the Rat Embryo Neural Crest Culture. Mamashli, Maliheh; Ramezani, Mina; Parsa, Maliheh; Ostad, Seyyed Nasser // Iranian Journal of Pharmaceutical Research;Dec2011, Vol. 10 Issue 4, p869 

    Enamel matrix derivative Emdogain (EMD) is widely used in periodontal treatment in spite of the fact that its effect on the developing embryo has not been elucidated. The aim of this study was to investigate the teratogenic effect of EMD on the rat embryo neural crest cells. The neural crest is...

  • Development of a Streamlined Rat Whole Embryo Culture Assay for Classifying Teratogenic Potential of Pharmaceutical Compounds. Zhang, Cindy; Cao, June; Kenyon, James R.; Panzica-Kelly, Julieta M.; Gong, Lei; Augustine-Rauch, Karen // Toxicological Sciences;Jun2012, Vol. 127 Issue 2, p535 

    This study describes a novel rat whole embryo culture (rWEC) teratogenicity assay that applies a simplified experimental design and statistical prediction model, resulting in reduced animal requirements and increased throughput with low prediction error rate for classifying teratogenic potential...

  • Follow-Up Studies of Cortisone Teratogenicity in CD1 Strain Mice. LOEVY, HANNELORE T. // Journal of Dental Research;Jul1976, Vol. 55 Issue 4, p598 

    Female newborns of cortisone-injected CD1 strain of mice were mated to siblings, were then injected during pregnancy with 5 mg of cortisone on either the 11th or the 12th day of gestation, and were killed one day after delivery. The incidence of induced cleft palate was as high as the incidence...

  • Prevention of Vitamin A Teratogenesis by Phytol or Phytanic Acid Results from Reduced Metabolism of Retinol to the Teratogenic Metabolite, All-trans-retinoic Acid. Arnhold, Thomas; Elmazar, Mohamed M. A.; Nau, Heinz // Toxicological Sciences;Apr2002, Vol. 66 Issue 2, p274 

    Previous studies in our laboratory showed a synergistic interaction of synthetic ligands selective for the retinoid receptors RAR and RXR in regard to teratogenic effects produced in mice (M. M. Elmazar et al., 2001, Toxicol. Appl. Pharmacol. 170, 2–9). In the present study the influence...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics