TITLE

ALDOSTERONE

PUB. DATE
January 2006
SOURCE
Davis's Comprehensive Handbook of Laboratory & Diagnostic Tests ;Jan2006, p24
SOURCE TYPE
Book
DOC. TYPE
Article
ABSTRACT
Aldosterone is a mineralocorticoid secreted by the zona glomerulosa of the adrenal cortex in response to decreased serum sodium, decreased blood volume, and increased serum potassium. Aldosterone increases sodium reabsorption in the renal tubules, resulting in potassium excretion and increased water retention, blood volume, and blood pressure. A variety of factors influence serum aldosterone levels, including sodium intake, certain medications, and activity. This test is of little diagnostic value unless plasma renin activity is measured simultaneously (see monograph titled “Renin”). Patients with serum potassium less than 3.6 mEq/L and 24-hour urine potassium greater than 40 mEq/L fit the general criteria to test for aldosteronism. Renin is low in primary aldosteronism and high in secondary aldosteronism. A ratio of plasma aldosterone to plasma renin activity greater than 50 is significant.
ACCESSION #
19566918

 

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