A molecular revolution in the study of intestinal microflora

Furrie, E.
February 2006
Gut;Feb2006, Vol. 55 Issue 2, p141
Academic Journal
Bacterial colonisers of the colon comprise several hundred bacterial species that live in a complex ecosystem. Study of this complex ecosystem has been carried out, until recently, by traditional culture techniques with biochemical methods to identify organisms. The development of molecular techniques to investigate ecological microbial communities has provided the microbiologist with a vast array of new techniques to investigate human intestinal microflora. Metagenomics, the science of biological diversity, combines the use of molecular biology and genetics to identify and characterise genetic material from complex microbial environments. The combination of metagenomics and subsequent quantitation of each identified species using molecular techniques allows the relatively rapid analysis of whole bacterial populations in human health and disease


Related Articles

  • Abdominal Accommodation: A Coordinated Adaptation of the Abdominal Wall to Its Content. Villoria, Albert; Azpiroz, Fernando; Soldevilla, Alfredo; Perez, Frederic; Malagelada, Juan-Ramon // American Journal of Gastroenterology;Nov2008, Vol. 103 Issue 11, p2807 

    BACKGROUND AND AIM: We previously showed that colonic gas infusion increases the girth and modifies the muscular activity of the anterior abdominal wall. We hypothesized that abdominal accommodation to volume loads is an active process instrumented by the coordinated activity of the anterior...

  • Stercoral Perforation of the Colon: Report of a New Location. Lui, Raphael C.; Herz, Burton; Plantilla, Eduardo; Davidson, Anthony L.; Cunningham Jr., Joseph N. // American Journal of Gastroenterology;Apr1988, Vol. 83 Issue 4, p457 

    Stercoral perforations of the colon unassociated with obstructive lesions are rarely reported. With the exception of one case report which described a stercoral perforation of the cecum, all the reported perforations occurred at the sigmoid or rectosigmoid colon. This report describes a new...

  • Getting to the Bottom of Colon Cleansing. Benhamu, Joanne // Australasian Science;Mar2014, Vol. 35 Issue 2, p46 

    The article reports on the history of colon cleansing therapy. Arthur Hurst, founder of the British Society of Gastroenterology, said in 1935 that colon is the most misunderstood organ in the body. Roman physician and philosopher, Galen, brought concept of miasmas (airborne particles) given off...

  • FURTHER OBSERVATIONS ON REVERSIBLE VASCULAR OCCLUSION OF THE COLON. Boley, Scott J.; Schwartz, Solomon; Krieger, Harvey; Schultz, Leon; Siew, Fred; Allen, Arthur C. // American Journal of Gastroenterology;Sep1965, Vol. 44 Issue 3, p260 

    Provides information on a study on reversible vascular occlusion of the colon presented before the Course in Postgraduate Gastroenterology of the American College of Gastroenterology in New York City from October 22 to 24, 1964. Manifestations of the disease; Factors to consider in making...

  • Sticking your 'ose in it: Prebiotics. McCarthy, Karl C.; Rastall, Robert A. // Biologist;Dec2003, Vol. 50 Issue 6, p259 

    Defines and evaluates the role of prebiotics in gut health. Reason of low incidence of gut disorder in breast-fed infants; Consequences of toxic metabolites formed during fermentation of foods in the colon; Description of bacterial fermentation in the large intestine.

  • A comparative study on adhesion and recovery of potential probiotic strains of Lactobacillus spp. by in vitro assay and analysis of human colon biopsies. LARSEN, NADJA; MICHAELSEN, KIM F.; PÆRREGAARD, ANDERS; VOGENSEN, FINN K.; JAKOBSEN, MOGENS // Microbial Ecology in Health & Disease;Jun2009, Vol. 21 Issue 2, p95 

    Adhesion of the new Lactobacillus isolates, L. casei D12, L. casei Q85, L. casei Z11 and L. plantarum Q47, to the porcine intestinal cell line IPEC-J2 was investigated and compared to the recovery of the same bacterial strains from colon biopsies and faeces obtained from human intervention...

  • LIPOMAS OF THE COLON. Deeb, Paul H.; Gardiner, Geoffrey A. // American Journal of Gastroenterology;Feb1963, Vol. 39 Issue 2, p150 

    Provides information on the incidence of lipomas of the colon in the U.S. Symptoms of the disease; Types of lipomas of the colon; Clinical features.

  • Effect of Pedunculated Liver Masses on the Colon. Baer, Jeanne W.; Abiri, Manoochehr; Marshak, Richard H.; Lindner, Arthur E. // American Journal of Gastroenterology;Mar1981, Vol. 75 Issue 3, p233 

    Two examples of displacement of the hepatic flexure of the colon superiorly and posteriorly by a pedunculated mass arising from the anterior lip of the right lobe of the liver are presented.

  • Advances in interventional gastrointestinal endoscopy in colon and rectum. Seitz, Uwe; Seewald, Stefan; Bohnacker, Sabine; Soehendra, Nib // International Journal of Colorectal Disease;Jan2003, Vol. 18 Issue 1, p12 

    Background. Instrumental and procedural advances particularly in the therapeutic field have been achieved. Review. Endoscopes with larger working channel, additional jet-channel, or variable stiffness allow more sophisticated interventional procedures. Higher resolution in endoscopic image...


Read the Article


Sign out of this library

Other Topics