Adjunctive treatment with eplerenone reduced 30-day all-cause mortality in acute myocardial infarction

January 2006
ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p15
Academic Journal
This article focuses on a study conducted to examine the efficacy of eplerenone in reducing 30-day all-cause mortality in acute myocardial infarction (MI). Randomized placebo-controlled trial was conducted on 6632 patients with acute MI complicated by left-ventricular systolic dysfunction and heart failure. Rates of all-cause mortality and death from cardiovascular causes were lower in the eplerenone group than in the placebo group. The groups did not differ for any other outcomes. It was concluded that in patients with acute myocardial infarction complicated by left-ventricular systolic dysfunction and heart failure, adjunctive treatment with eplerenone reduced 30-day all-cause mortality more than placebo.


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