Lamotrigine or gabapentin was better tolerated than carbamazepine in new-onset geriatric epilepsy: COMMENTARY

Mayes, Bruce N.
January 2006
ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p6
Academic Journal
This article comments on a study conducted to compare the efficacy of lamotrigine over carbamazepine in new-onset geriatric epilepsy. Older patients have a high incidence of new-onset epilepsy, which often responds to moderate doses of an appropriate anticonvulsant in monotherapy. However, choosing an appropriate anticonvulsant for older patients can be complicated. Furthermore, given their typically reduced hepatic and renal function and baseline neurologic impairments, older patients are especially susceptible to systemic and neurotoxic adverse effects. Researchers provided valuable evidence that gabapentin and lamotrigine in monotherapy were effective for new-onset seizures in older patients and were better tolerated than carbamazepine.


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