Peginterferon α-2a alone or with lamivudine increased response rates more than lamivudine alone for HBeAg-positive chronic hepatitis B

January 2006
ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p5
Academic Journal
This article focuses on a clinical study to compare the effectiveness of peginterferon α2a, and lamivudine, in patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis B. 814 patients who had been positive for hepatitis B surface antigen (HBsAg) for age of 6 months were negative for antibodies to HBsAg and positive for HBeAg. At 24 weeks after stopping treatment, patients who received peginterferon α2a, alone or plus lamivudine, had higher rates of HBeAg seroconversion, suppression of HBV DNA levels, and combined response than did those who received lamivudine monotherapy.


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