TITLE

Review: Additional anti-gram-positive antibiotics do not reduce all-cause mortality in cancer and febrile neutropenia: COMMENTARY

AUTHOR(S)
Aoun, Mickael
PUB. DATE
January 2006
SOURCE
ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article comments on a study conducted to examine the efficacy of anti-gram-positive (anti-GP) antibiotics in reducing all-cause mortality in cancer and febrile neutropenia. Most gram-positive cocci that cause bacteremia in neutropenic patients falls into two categories. The first category includes coagulase-negative staphylococci, Corynebacterium jeikeium, stomatococci, and enterococci, which are usually indolent, so treatment can often be safely deferred until formal microbiological identification. The second category includes Streptococcus viridans and Staphylococcus aureus, which are virulent, are often resistant to penicillin and methicillin, and can cause substantial morbidity and mortality before formal microbiological identification. Researchers analyzed data from 13 RCTs to determine whether adding anti-GP antibiotics reduced mortality and morbidity in patients with cancer and febrile neutropenia after chemotherapy.
ACCESSION #
19515980

 

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