Review: Additional anti-gram-positive antibiotics do not reduce all-cause mortality in cancer and febrile neutropenia: COMMENTARY

Aoun, Mickael
January 2006
ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p3
Academic Journal
This article comments on a study conducted to examine the efficacy of anti-gram-positive (anti-GP) antibiotics in reducing all-cause mortality in cancer and febrile neutropenia. Most gram-positive cocci that cause bacteremia in neutropenic patients falls into two categories. The first category includes coagulase-negative staphylococci, Corynebacterium jeikeium, stomatococci, and enterococci, which are usually indolent, so treatment can often be safely deferred until formal microbiological identification. The second category includes Streptococcus viridans and Staphylococcus aureus, which are virulent, are often resistant to penicillin and methicillin, and can cause substantial morbidity and mortality before formal microbiological identification. Researchers analyzed data from 13 RCTs to determine whether adding anti-GP antibiotics reduced mortality and morbidity in patients with cancer and febrile neutropenia after chemotherapy.


Related Articles

  • Changes in the Etiology of Bacteremia in Febrile Neutropenic Patients and the Susceptibilities of the Currently Isolated Pathogens. Ramphal, Reuben // Clinical Infectious Diseases;7/1/2004 Supplement 1, Vol. 39, pS25 

    The etiology of bacteremia in febrile neutropenic patients in the past few decades has shifted from gram-negative to gram-positive organisms. Potential reasons include the use of indwelling catheters, local environ-mental conditions, and the administration of specific antibiotic agents,...

  • Functional synergy of α-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo. Feng, Q.; Huang, Y.; Chen, M.; Li, G.; Chen, Y. // European Journal of Clinical Microbiology & Infectious Diseases;Jan2015, Vol. 34 Issue 1, p197 

    In this study, the antimicrobial activities based on the synergistic effects of traditional antibiotics (imipenem, cefepime, levofloxacin hydrochloride and vancomycin) and antimicrobial peptides (AMPs; PL-5, PL-31, PL-32, PL-18, PL-29 and PL-26), alone or in combination, against three...

  • Review: Additional anti-gram-positive antibiotics do not reduce all-cause mortality in cancer and febrile neutropenia.  // ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p3 

    This article reports on a study conducted to examine the efficacy of anti-gram-positive (anti-GP) antibiotics in reducing all-cause mortality in cancer and febrile neutropenia. Randomized or quasi-randomized controlled trials (RCTs) were studied, comparing a standard antibiotic regimen with the...

  • MRSA in the community. Simon, Chantal // InnovAiT;Feb2009, Vol. 2 Issue 2, p74 

    Staphylococcus aureus (Fig. 1) is a gram-positive bacterium that is a common colonizer of human skin and mucosa. It can cause disease, particularly if there is an opportunity for the bacteria to enter the body. A small proportion of S. aureus bacteria is resistant to methicillin and other...

  • A Review of the Carbapenems in Clinical Use and Clinical Trials. Lo, Tze S.; Welch, Justin M.; Alonto, Augusto M.; Vicaldo-Alonto, Eileen A. R. // Recent Patents on Anti-Infective Drug Discovery;Jun2008, Vol. 3 Issue 2, p123 

    Despite alarming data showing the ever increasing number of bacteria becoming resistant to different classes of antibiotics through various mechanisms, the carbapenems remain a unique class of antibiotics that possess the broadest spectrum against Gram-positive, Gram-negative, aerobic and...

  • The Cell Wall Stress Stimulon of Staphylococcus aureus and Other Gram- Positive Bacteria. Wilkinson, Brian J.; Muthaiyan, Arunachalam; Jayaswal, Radheshyam K. // Current Medicinal Chemistry - Anti-Infective Agents;Jul2005, Vol. 4 Issue 3, p259 

    By the early nineteen seventies the mechanism of inhibition of peptidoglycan biosynthesis by various cell wallactive antibiotics was well established, and the Gram-positive bacterium Staphylococcus aureus had often been used in the studies. From the early days of penicillin it was known that...

  • Daptomycin: Safe at Higher Doses? Blackburn, Brian // Infectious Disease Alert;Aug2009, Vol. 28 Issue 11, p85 

    Daptomycin is a lipopeptide antibiotic that exhibits concentration-dependent bactericidal activity against a wide array of gram-positive organisms. It is approved for the treatment of complicated skin and soft-tissue infections (SSTI) at a dose of 4 mg/kg/day, as well as for Staphylococcus...

  • ANTIBIOTIC SUSCEPTIBILITY PATTERN OF STAPHYLOCOCCUS AUREUS STRAINS FROM PATIENTS IN ETHIOPIA. Wubishet, Befikadu Legesse; Sabe, Zewdneh Shewamene; Alemu, Hailemeskel Mekonnen; Z/Mariam, Fetene Deribe // International Journal of Pharmaceutical Sciences & Research;Dec2012, Vol. 3 Issue 12, p4889 

    Staphylococcus aureus (S. aureus) is one of the most serious gram-positive bacteria causing several infections. Because of its intrinsic ability to develop resistance to many antibiotics, nowadays only few drugs can be confidently mentioned for the treatment of S. aureus infections. The study...

  • Design and high-level expression of a hybrid antimicrobial peptide LF15-CA8 in Escherichia coli. Feng, Xing-Jun; Xing, Li-Wei; Liu, Di; Song, Xue-Ying; Liu, Chun-Long; Li, Jing; Xu, Wen-Shan; Li, Zhong-Qiu // Journal of Industrial Microbiology & Biotechnology;Mar2014, Vol. 41 Issue 3, p527 

    Antimicrobial peptides (AMPs) have been paid considerable attention owing to their broad-spectrum antimicrobial activity and have great potential as novel antimicrobials. In this study, a novel hybrid peptide LF15-CA8 was designed on the basis of bovine lactoferricin (LfcinB) and cecropin A. The...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics