TITLE

Review: Additional anti-gram-positive antibiotics do not reduce all-cause mortality in cancer and febrile neutropenia

PUB. DATE
January 2006
SOURCE
ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article reports on a study conducted to examine the efficacy of anti-gram-positive (anti-GP) antibiotics in reducing all-cause mortality in cancer and febrile neutropenia. Randomized or quasi-randomized controlled trials (RCTs) were studied, comparing a standard antibiotic regimen with the same regimen plus an anti-GP antibiotic for empirical treatment of patients with cancer and febrile neutropenia. Meta-analysis of 7 RCTs showed that the addition of an anti-GP antibiotic did not reduce all-cause mortality. The addition of an anti-GP antibiotic resulted in fewer treatment failures if treatment modifications were counted as failures, but not if treatment modifications were ignored.
ACCESSION #
19515979

 

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