Review: Additional anti-gram-positive antibiotics do not reduce all-cause mortality in cancer and febrile neutropenia

January 2006
ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p3
Academic Journal
This article reports on a study conducted to examine the efficacy of anti-gram-positive (anti-GP) antibiotics in reducing all-cause mortality in cancer and febrile neutropenia. Randomized or quasi-randomized controlled trials (RCTs) were studied, comparing a standard antibiotic regimen with the same regimen plus an anti-GP antibiotic for empirical treatment of patients with cancer and febrile neutropenia. Meta-analysis of 7 RCTs showed that the addition of an anti-GP antibiotic did not reduce all-cause mortality. The addition of an anti-GP antibiotic resulted in fewer treatment failures if treatment modifications were counted as failures, but not if treatment modifications were ignored.


Related Articles

  • Review: Additional anti-gram-positive antibiotics do not reduce all-cause mortality in cancer and febrile neutropenia: COMMENTARY. Aoun, Mickael // ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p3 

    This article comments on a study conducted to examine the efficacy of anti-gram-positive (anti-GP) antibiotics in reducing all-cause mortality in cancer and febrile neutropenia. Most gram-positive cocci that cause bacteremia in neutropenic patients falls into two categories. The first category...

  • Changes in the Etiology of Bacteremia in Febrile Neutropenic Patients and the Susceptibilities of the Currently Isolated Pathogens. Ramphal, Reuben // Clinical Infectious Diseases;7/1/2004 Supplement 1, Vol. 39, pS25 

    The etiology of bacteremia in febrile neutropenic patients in the past few decades has shifted from gram-negative to gram-positive organisms. Potential reasons include the use of indwelling catheters, local environ-mental conditions, and the administration of specific antibiotic agents,...

  • Two Novel Anticancer Peptides from Aurein1.2. Karbalaeemohammad, Shahrbanoo; Naderi-Manesh, Hossein // International Journal of Peptide Research & Therapeutics;Sep2011, Vol. 17 Issue 3, p159 

    Aurein1.2 is a cationic peptide with antimicrobial and anticancer activity. In order to find a novel peptide with this activity, aurein1.2 was utilized as a template and the sequences were designed by a RosettaDesign server with our proposed pattern. As a result, tempY was designed and...

  • teicoplanin.  // Royal Society of Medicine: Medicines;2002, p525 

    The article presents information on the teicoplanin drug which is an antibacterial and antibiotic drug of the glycopeptide family. It has activity primarily against Gram-positive bacteria, inhibiting the synthesis of components of the bacterial cell wall. This drug can be used in the treatment...

  • Bioactive metabolite production by Streptomyces albolongus in favourable environment. Uddin, Myn; Mahmud, Nuruddin; Anwar, Nural; Manchur, Mohammed Abul // Journal of Microbiology & Infectious Diseases;Jun2013, Vol. 3 Issue 2, p75 

    Objectives: Demand for new antibiotic is rising up due to continuous resistance risk against conventional antibiotic. This attempt was taken to find out a novel antimicrobial metabolite. Methods: Chili field antagonistic actinomycetes Streptomyces albolongus was isolated and tested for optimum...

  • Talking microbes.  // Nature Chemical Biology;Jan2012, Vol. 8 Issue 1, p1 

    The author discusses the impact of microbe interactions on antimicrobial drug design and the concepts related to bacteria. An overview of several studies on the developments of pharmacological agents including antifungal and antibacterial compounds and antibiotics is offered. Also investigated...

  • Antibiotic Combinations with Redundant Antimicrobial Spectra: Clinical Epidemiology and Pilot Intervention of Computer-Assisted Surveillance. Glowacki, Robert C.; Schwartz, David N.; Itokazu, Gail S.; Wisniewski, Mary F.; Kieszkowski, Piotr; Weinstein, Robert A. // Clinical Infectious Diseases;7/1/2003, Vol. 37 Issue 1, p59 

    Redundant antibiotic combinations are a potentially remediable source of antibiotic overuse. At a public teaching hospital, we determined the incidence, cost, and indications for such combinations and measured the effects of a pharmacist-based intervention. Of 1189 inpatients receiving ⩾ 2...

  • Análisis de los tratamientos utilizados en las infecciones por cocos grampositivos multirresistentes en pacientes críticos ingresados en UCI. Álvarez-Lerma, Francisco; Martínez, Mercedes Palomar; Astigarraga, Pedro Olaechea; Ordeñana, Josu Insausti; López Pueyo, María Jesús; Gracia Arnillas, María Pilar; Costa, Ricardo Gimeno; Betolaza, Iratxe Seijas // Revista Española de Quimioterapia;mar2012, Vol. 25 Issue 1, p65 

    The appearance of new antimicrobials with activity against Gram-positive multiresistant cocci and knowledge of the limitations of glycopeptides has represented an important change in the use of these antibiotics. Objetive. To analyze at the national level changes in the use of antibiotics with...

  • Determining Chemical Composition and Antimicrobial Activity of Feverfew (Tanacetum parthenium L.) Essential Oil on Some Microbial Strains. Izadi, Zahra; Aghaalikhani, Majid; Esna-Ashari, PMahmood; Davoodi, Poorandokht // Zahedan Journal of Research in Medical Sciences;Jun2013, Vol. 15 Issue 6, p8 

    Background: Feverfew (Tanacetum parthenium L.) is a herbal plant that has anti- septic, anti-microbial, anti-parasitic and anti-inflammatory effects. The main objective of this study is to evaluate the antimicrobial effect of shoot essential oil (essential oil of the aerial parts of the plant)...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics