Trimethoprim reduced dysuria in women with symptoms of urinary tract infection but negative urine dipstick test results: COMMENTARY

Leibovici, Leonard
January 2006
ACP Journal Club;Jan/Feb2006, Vol. 144 Issue 1, p1
Academic Journal
This article focuses on a clinical study according to which the prevalence of urinary symptoms in women 40 to 60 years of age is about 30%, and the yearly incidence is 10%. To offer antibiotic treatment to a large proportion of symptomatic women regardless of urine findings would have staggering effects in terms of side effects and induction of resistance. The methodology and reporting of the study are excellent. However, a major question exists about external validity in that only about 20% of eligible persons were recruited. Such a group willing to take antibiotics might include more persons likely to have bacterial urinary tract infections. A similar study should examine the overall response to antibiotic treatment, as well as the value of clinical symptoms and signs and their combination and of laboratory tests to predict response to antibiotics.


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