Pinning the tail on the substrate

Eisenstein, Michael
February 2006
Nature Methods;Feb2006, Vol. 3 Issue 2, p74
Academic Journal
Two high-throughput 'kinomic' analysis strategies could provide kinase researchers with a bounty of information about the targets and the regulation of their favorite enzymes.


Related Articles

  • Journal Club. De Broe, Marc; Schlöndorff, Detlef; Oliver, Juan // Kidney International;Aug2006, Vol. 70 Issue 3, p415 

    The article presents various research on nephrology. A data on a research about hitting the hot spots of cell signaling cascades with small molecules, demonstrates an approach for specific modulation of G protein coupled receptor signaling that may represent an important therapeutic strategy....

  • Snf1 Controls the Activity of Adr1 Through Dephosphorylation of Ser230. Ratnakumar, Sooraj; Kacherovsky, Nataly; Arms, Erin; Young, Elton T. // Genetics;Jul2009, Vol. 182 Issue 3, p735 

    The transcription factors Adr1 and Cat8 act in concert to regulate the expression of numerous yeast genes after the diauxic shift. Their activities are regulated by Snf1, the yeast homolog of the AMP-activated protein kinase of higher eukaryotes. Cat8 is regulated directly by Snf1, but how Snf1...

  • Mical links semaphorins to F-actin disassembly. Ruei-Jiun Hung; Yazdani, Umar; Jimok Yoon; Heng Wu; Taehong Yang; Nidhi Gupta; Zhiyu Huang; van Berkel, Willem J. H.; Terman, Jonathan R. // Nature;2/11/2010, Vol. 463 Issue 7282, p823 

    How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studied for their effects on cell movement, navigation, angiogenesis, immunology and...

  • Spread the word. Bussell, Katrin // Nature Reviews Genetics;Sep2004 Supplement, Vol. 5, p4 

    Discusses research being done on proteins that are present in focal adhesions. Reference to a study by Matthias Mann and colleagues published in the "Cell" journal; Identification of the spreading initiation centre, an early cell-spreading structure that contains RNA and RND-binding proteins;...

  • Inhibition of focal adhesion kinase induces apoptosis in human gastric carcinoma cells (SGC-7901). Li, Jiyou; Meng, Qingfeng; Sun, Yu; Qing, Huadong // Molecular Biology Reports;Jan2013, Vol. 40 Issue 1, p401 

    Focal adhesion kinase (FAK), a non-receptor tyrosine kinase protein, acts as an early modulator of integrin signaling cascade, regulating basic cellular functions. In transformed cells, unopposed FAK signaling has been considered to promote tumor growth, progression and metastasis. The aim of...

  • FAK Acts as a Suppressor of RTK-MAP Kinase Signalling in Drosophila melanogaster Epithelia and Human Cancer Cells. Macagno, Juan Pablo; Diaz Vera, Jesica; Yu, Yachuan; MacPherson, Iain; Sandilands, Emma; Palmer, Ruth; Norman, Jim C.; Frame, Margaret; Vidal, Marcos // PLoS Genetics;Mar2014, Vol. 10 Issue 3, p1 

    Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream signalling. Here we investigated how FAK...

  • AKAP12 and AKAP5 form higher-order heterooligomers.  // Journal of Molecular Signaling;2011, Vol. 6 Issue 1, p8 

    The article presents a study conducted to examine the potential of A-kinase-anchoring proteins, AKAPs including AKAP12 and AKAP5 in forming higher-order heterooligomers. It mentions that the family of AKAPs constitutes a group of molecular scaffolds that act to catalyze dynamic interactions of...

  • Cell migration: Talin heads off. Baumann, Kim // Nature Reviews Molecular Cell Biology;Jun2009, Vol. 10 Issue 6, p368 

    The article summarizes a recent article describing research on the importance of talin to cell migration. It states that the kinase CDK5 regulates focal adhesion disassembly through phosphorylation of talin, disabling the binding of SMURF1 to the talin head domain, which is necessary for the...

  • Re-annotation of the CAZy genes of Trichoderma reesei and transcription in the presence of lignocellulosic substrates. H„kkinen, Mari; Arvas, Mikko; Oja, Merja; Aro, Nina; Penttil„, Merja; Saloheimo, Markku; Pakula, Tiina M. // Microbial Cell Factories;2012, Vol. 11 Issue 1, p134 

    Background: Trichoderma reesei is a soft rot Ascomycota fungus utilised for industrial production of secreted enzymes, especially lignocellulose degrading enzymes. About 30 carbohydrate active enzymes (CAZymes) of T. reesei have been biochemically characterised. Genome sequencing has revealed a...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics