Different strokes for rodent folks

Flaumenhaft, Robert; Lo, Eng H.
February 2006
Nature Methods;Feb2006, Vol. 3 Issue 2, p79
Academic Journal
The article discusses a stroke model which couples the two-photon laser scanning mapping of the cerebral cortex with femtosecond laser technology to produce microvascular injuries which are characterized by hemorrhage, vessel leakage and vessel occlusion. The tissue injury resulting from femtosecond pulses of laser light differs from injuries caused by long-pulsed lasers. The injury is not secondary to the heating of tissue because the femtosecond laser pulses do not result in a thermal effect. The nonlinear processes enabled the localization of photons which reduce the energy threshold for tissue injury and limit damage to adjacent tissue.


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