NMR mapping of protein interactions in living cells

Selenko, Philipp; Wagner, Gerhard
February 2006
Nature Methods;Feb2006, Vol. 3 Issue 2, p80
Academic Journal
The article focuses on an application of in-cell nuclear magnetic resonance spectroscopy which analyzes the structural changes that go with protein-protein interactions in vivo and at atomic resolution. The attempts to develop new in vivo techniques for structural biology and cellular imaging aim to allow the study of biomolecules in their natural environment. Nuclear magnetic resonance spectroscopy is the only other method for the structural investigation of biomolecules at the atomic level, also in the structural investigation of labeled proteins in vivo and inside cells.


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