Molecular and Epidemiologic Trends of Caliciviruses Associated with Outbreaks of Acute Gastroenteritis in the United States, 2000-2004

Blanton, Lenee H.; Adams, Susan M.; Beard, R. Suzanne; Wei, Gang; Bulens, Sandra N.; Widdowson, Marc-Alain; Glass, Roger I.; Monroe, Stephan S.
February 2006
Journal of Infectious Diseases;2/1/2006, Vol. 193 Issue 3, p413
Academic Journal
Between July 2000 and June 2004, fecal specimens from 270 outbreaks of acute gastroenteritis were sent to the Centers for Disease Control and Prevention by local or state health departments for calicivirus testing. Of the 226 outbreaks that met the criteria for inclusion in the present study, caliciviruses were detected in 184 (81%) by reverse-transcription polymerase chain reaction and nucleotide sequencing. Nursing homes, retirement centers, and hospitals were the most frequently reported settings, and person-to-person contact was the most common mode of transmission, followed by foodborne spread. Overall, genogroup II norovirus (NoV) strains were the most abundant (79%), followed by genogroup I NoV strains (19%) and sapovirus (2%). Nucleotide-sequence analysis indicated a great diversity of NoV strains and implicated the emergence of one particular sequence variant in outbreaks occurring between July 2002 and June 2003. The public health impact of caliciviruses will not be fully appreciated, nor will interventions be completely evaluated, until methods to detect these viruses are more routinely used.


Related Articles

  • Norovirus Illness Is a Global Problem: Emergence and Spread of Norovirus GII.4 Variants, 2001-2007. Siebenga, J. Joukje; Vennema, Harry; Du-Ping Zheng; Vinjé, Jan; Lee, Bonita E.; Xiao-Li Pang; Ho, Eric C. M.; Lim, Wilina; Choudekar, Avinash; Broor, Shobha; Halperin, Tamar; Rasool, Nassar B. G.; Hewitt, Joanne; Greening, Gail E.; Miao Jin; Zhao-Jun Duan; Lucero, Yalda; O'Ryan, Miguel; Hoehne, Marina; Schreier, Eckart // Journal of Infectious Diseases;9/1/2009, Vol. 200 Issue 5, p802 

    Background. Noroviruses (NoVs) are the most common cause of viral gastroenteritis. Their high incidence and importance in health care facilities result in a great impact on public health. Studies from around the world describing increasing prevalence have been difficult to compare because of...

  • Norwalk-Like Virus-Associated Gastroenteritis in a Large, High-Density Encampment -- Virginia, July 2001.  // MMWR: Morbidity & Mortality Weekly Report;8/2/2002, Vol. 51 Issue 30, p661 

    Describes an outbreak of Norwalk-like viruses (NLV) associated gastroenteritis at a large youth encampment in Virginia and the successful use of control measures to limit the spread of the illness to other campers. Transmission of the viruses to settings of crowding and poor sanitation; Number...

  • Gastroenteritis Outbreak at Holiday Resort, Central Italy. Migliorati, Giacomo; Prencipe, Vincenza; Ripani, Alessandro; Di Francesco, Cristina; Casaccia, Claudia; Crudeli, Silvia; Ferri, Nicola; Giovannini, Armando; Marconi, Maria Maddalena; Marfoglia, Cristina; Melai, Valeria; Savini, Giovanni; Scortichini, Giampiero; Semprini, Primula; Ruggeri, Franco Maria // Emerging Infectious Diseases;Mar2008, Vol. 14 Issue 3, p474 

    During the summer of 2003, a gastroenteritis outbreak spread throughout a holiday resort in central Italy. Fecally contaminated groundwater and seawater were leaking into the non-drinking-water system, which was found to be connected to the drinking-water system of a large resort. This...

  • An Efficient and Rapid Method for Recovery of Norovirus from Food Associated with Outbreaks of Gastroenteritis. Boxman, Ingeborg L. A.; Tilburg, Jeroen J. H. C.; Te Loeke, Nathalie A. J. M.; Vennema, Harry; De Boer, Enne; Koopmans, Marion // Journal of Food Protection;Feb2007, Vol. 70 Issue 2, p504 

    Noroviruses have emerged as the most common cause of foodborne outbreaks of acute nonbacterial gastroenteritis. In this study, two methods for the extraction of viruses from deli ham were compared. Using both methods, as little as 1 to 10 reverse transcription (RT)-PCR units of inoculated...

  • Molecular Epidemiology of Human Enteric Caliciviruses in The Netherlands. Koopmans, Marion; Vinje, Jan; de Wit, Matty; Leenen, Imke; van der Poel, Wim; van Duynhoven, Yvonne // Journal of Infectious Diseases;5/15/2000 Supplement 2, Vol. 181, pS262 

    Reports on the molecular epidemiology of human enteric caliciviruses in the Netherlands. Outbreaks of gastroenteritis attributed to Norwalk-like viruses; Patterns of disease activity; Transmission.

  • Epidemiology of Calicivirus Infections in Sweden, 1994-1998. Hedlund, K.O.; Rubilar-Abreu, E.; Svensson, L. // Journal of Infectious Diseases;5/15/2000 Supplement 2, Vol. 181, pS275 

    Investigates the epidemiology of caliciviruses infections in Sweden from 1994-1998. Role of caliciviruses in gastroenteritis; Norwalk-like viruses; Causes of nosocomial and community-associated outbreaks.

  • Genetic diversity of porcine enteric caliciviruses in pigs raised in Rio de Janeiro State, Brazil. Cunha, Juliana Bragazzi; de Mendonça, Marcos César Lima; Miagostovich, Marize Pereira; di Leite, José Paulo Gagliar // Archives of Virology;Aug2010, Vol. 155 Issue 8, p1301 

    Porcine enteric caliciviruses (PEC) belong to the genera Norovirus and Sapovirus within the family Caliciviridae. They are enteric pathogens and are considered potential zoonotic agents. In this study, the circulation of PEC was evaluated by RT-PCR of stool samples and intestinal contents of...

  • Inactivation of the Tulane Virus, a Novel Surrogate for the Human Norovirus. PENG TIAN; YANG, DAVID; QUIGLEY, CHRISTINA; CHOU, MARISSA; XI JIANG // Journal of Food Protection;Apr2013, Vol. 76 Issue 4, p712 

    Human noroviruses (HuNoVs) are the major cause of nonbacterial gastroenteritis epidemics. The culturable feline calicivirus and murine norovirus have been used extensively as surrogates to study HuNoV biology, as HuNoV does not grow in vitro. Additional efforts to identify new surrogates are...

  • Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis. Patel, Manish M.; Widdowson, Marc-Alain; Glass, Roger I.; Akazawa, Kenichiro; Vinjé, Jan; Parashar, Umesh D. // Emerging Infectious Diseases;Aug2008, Vol. 14 Issue 8, p1224 

    We conducted a systematic review of studies that used reverse transcription-PCR to diagnose norovirus (NoV) infections in patients with mild or moderate (outpatient) and severe (hospitalized) diarrhea. NoVs accounted for 12% (95% confidence interval [CI] 10%-15%) of severe gastroenteritis cases...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics