TITLE

Leucocyte-depleting arterial line filtration does not reduce myocardial injury assessed by Troponin T during routine coronary artery bypass grafting using crossclamp fibrillation

AUTHOR(S)
Whitaker, Donald C; Stygall, Jan; Harrison, Michael JG; Mackie, Ian J; Kemp, Michael; Hooper, James; Pugsley, Wilfred B; Newman, Stanton P
PUB. DATE
January 2006
SOURCE
Perfusion;Jan2006, Vol. 21 Issue 1, p55
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Leucocyte filtration can reduce inflammation and end-organ damage. The aim of this study was to test the cardioprotective effect of systemic leucocyte filtration during cardiopulmonary bypass (CPB) for coronary revascularization. Methods: Sixty patients scheduled for elective coronary artery bypass grafting were prospectively randomised to receive either a test leucocyte-depleting (LD) filter or a control standard arterial line filter in the CPB circuit. Myocardial injury was determined by serum Troponin T concentration up to 72 h postoperatively. In addition, perioperative neutrophil counts, serum elastase and electrocardiograms (ECGs) were evaluated. Results: There was a peak of Troponin T release at 6 h in both groups. There was no difference between LD or control group Troponin T at any time point. No difference in neutrophil count was found. A greater rise in neutrophil elastase occurred in the LD group during CPB and 10 min post CPB (376 and 496 versus 108 and 228 mcg/L, p < 0.001). Conclusions: LD arterial line filters did not confer any cardioprotective effect as measured by Troponin T in elective coronary revascularization cases.
ACCESSION #
19417360

 

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