TITLE

Pancreatic Cancer And Malignant Pleural Effusion

AUTHOR(S)
Barbetakis, Nikolaos; Krikeli, Marianthi; Vassiliadis, Michalis; Lyratzopoulos, Nikolaos; Efstathiou, Andreas; Tsilikas, Christodoulos
PUB. DATE
January 2006
SOURCE
Internet Journal of Surgery;2006, Vol. 7 Issue 1, p14
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Aim of this study was to assess the efficacy of mitoxantrone sclerotherapy as a palliative treatment of malignant pleural effusions due to pancreatic cancer. Methods: Twenty-nine patients with known pancreatic cancer and malignant recurrent symptomatic pleural effusion were treated with chest tube drainage followed by intrapleural mitoxantrone sclerotherapy. Survival, complications and response to pleurodesis according to clinical and radiographic criteria were recorded. The data are expressed as the mean ± standard error of the mean (SEM) and the median. Results: The mean age of the entire group was 52 ± 10,27 years. The mean interval between diagnosis of pancreatic cancer and presentation of the effusion was 6 ± 2,3 months. Six patients (20,6%) had pleural effusion as the first evidence of recurrence. The mean volume of effusion drained was 970 ± 105 ml and chest tube was removed within 4 days in 72,4% (21/29) of patients. There were no deaths related to the procedure. Side effects of chemical pleurodesis included mainly fever, chest pain, nausea and vomiting. At 30 days among 28 treated effusions (one patient died within 1 month of pleurodesis), there was an 85,7% (24/28 patients) overall response rate, including 20 complete responses and 4 partial responses. At 60 days the overall response was 75% (19 complete responses and 2 partial responses). The mean survival of the entire population was 6,3 ± 1,1 months. Conclusions: Mitoxantrone is effective in the treatment of malignant pleural effusion secondary to pancreatic cancer without causing significant local or systemic toxicity.
ACCESSION #
19405774

 

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