Pancreatic Cancer And Malignant Pleural Effusion

Barbetakis, Nikolaos; Krikeli, Marianthi; Vassiliadis, Michalis; Lyratzopoulos, Nikolaos; Efstathiou, Andreas; Tsilikas, Christodoulos
January 2006
Internet Journal of Surgery;2006, Vol. 7 Issue 1, p14
Academic Journal
Background: Aim of this study was to assess the efficacy of mitoxantrone sclerotherapy as a palliative treatment of malignant pleural effusions due to pancreatic cancer. Methods: Twenty-nine patients with known pancreatic cancer and malignant recurrent symptomatic pleural effusion were treated with chest tube drainage followed by intrapleural mitoxantrone sclerotherapy. Survival, complications and response to pleurodesis according to clinical and radiographic criteria were recorded. The data are expressed as the mean ± standard error of the mean (SEM) and the median. Results: The mean age of the entire group was 52 ± 10,27 years. The mean interval between diagnosis of pancreatic cancer and presentation of the effusion was 6 ± 2,3 months. Six patients (20,6%) had pleural effusion as the first evidence of recurrence. The mean volume of effusion drained was 970 ± 105 ml and chest tube was removed within 4 days in 72,4% (21/29) of patients. There were no deaths related to the procedure. Side effects of chemical pleurodesis included mainly fever, chest pain, nausea and vomiting. At 30 days among 28 treated effusions (one patient died within 1 month of pleurodesis), there was an 85,7% (24/28 patients) overall response rate, including 20 complete responses and 4 partial responses. At 60 days the overall response was 75% (19 complete responses and 2 partial responses). The mean survival of the entire population was 6,3 ± 1,1 months. Conclusions: Mitoxantrone is effective in the treatment of malignant pleural effusion secondary to pancreatic cancer without causing significant local or systemic toxicity.


Related Articles

  • Chemical Pleurodesis for Malignant Pleural Effusions. Walker-Renard, Pamela B.; Vaughan, Leigh M.; Sahn, Steven A. // Annals of Internal Medicine;1/1/94, Vol. 120 Issue 1, p56 

    Purpose: To provide information about available agents for chemical pleurodesis. Data Sources: A MEDLINE search (1966 to October 1992) was conducted using the terms malignant pleural effusion and pleurodesis. Study Selection: All articles containing references to patients with recurrent,...

  • Sclerotherapy is now available to outpatients. Wolfe, Suzanne // RN;Aug95, Vol. 58 Issue 8, p13 

    Reports that outpatient sclerotherapy for pleural efussion have been started by researchers in Maryland and Pittsburgh, Pennsylvania. Establishment of efussion drainage; Success rate of outpatient sclerotherapy.

  • Two stages of care for pleural effusion. Connor, Patricia; Berg, Pamela; Flaherty, Nancy; Klem, Linda; Lawton, Ramona; Tremblay, Marla // RN;Feb89, Vol. 52 Issue 2, p30 

    Discusses two stages of palliative care for pleural effusion. Cause and effect of pleural effusion; Signs and symptoms; Diagnostic tests for the disease.

  • pleurocentesis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1807 

    A definition of the medical term "pleurocentesis," which refers to thorancentesis, is presented.

  • pleuroclysis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1807 

    A definition of the medical term "pleuroclysis," which refers to injection and removal of fluid into the pleural cavity to wash it out, is presented.

  • The palliation of malignant pleural effusions. Bhatnagar, Rahul; Rahman, Najib M. // British Journal of Hospital Medicine (17508460);Jan2012, Vol. 73 Issue 1, p4 

    The authors offer information on malignant pleural effusions, a common complication of several cancers, and discuss their treatment and diagnosis. They mention that management of pleural effusions involves appropriate treatment for dyspnoea, and thoracocentesis or intercostal drain insertion for...

  • VATS decortication for trapped lung in malignant pleural effusion: results of surgery. Minchev, T.; Manolov, E.; Marinchev, V.; Angelov, A.; Stoimenov, I.; Penev, B. // Journal of Cardiothoracic Surgery;2013, Vol. 8 Issue Suppl 1, p1 

    An abstract of the article "VATS decortication for trapped lung in malignant pleural effusion: results of surgery" by T. Minchev, E. Manolov, V. Marinchev, A. Angelov, I. Stoimenov and B. Penev is presented.

  • Diagnosis disclosure in a Portuguese oncological centre. Gonçalves, J.F.; Castro, S. // Palliative Medicine;Jan2001, Vol. 15 Issue 1, p35 

    The disclosure of a diagnosis of cancer to patients is a controversial matter. There have been major differences in practice concerning this issue through time and between cultures. A questionnaire was sent to the doctors of the Oporto Centre of the Portuguese Institute of Oncology in order to...

  • Indwelling pleural catheters for malignant pleural effusion. McPhillips, Dympna; Breen, David // International Journal of Palliative Nursing;2015, Vol. 21 Issue 6, p266 

    Pleural effusions are a common cause of symptoms in patients with malignancy and can adversely affect quality of life. However, not all effusions in the setting of malignancy are due to the cancer itself and therefore it is essential to perform an extensive assessment to diagnose the underlying...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics