Hypothermia during reperfusion does not reduce myocardial infarct size in pigs

Maeng, Michael; Mortensen, Ulrik M.; Kristensen, Jens; Kristiansen, Steen B.; Andersen, Henning R.
January 2006
Basic Research in Cardiology;Jan2006, Vol. 101 Issue 1, p61
Academic Journal
We previously described a method for regional myocardial cooling that reaches the target temperature within 4 min. The present study evaluated whether this method for regional myocardial cooling during reperfusion reduces myocardial infarct size (IS) in 75–kg pigs. Myocardial infarction was induced by inflation of an angioplasty balloon in the left anterior descendent artery for 45 min followed by 3 h reperfusion. First, 15 pigs were randomized to regional myocardial cooling during reperfusion (n = 8) or control (n = 7). As further control experiments, systemic hypothermia was induced prior to ischemia (n = 3) and during reperfusion (n = 3). IS and area at risk (AAR) were evaluated in vivo by single photon emission cardiac tomography (SPECT) and by standard histochemical staining. Regional cooling during reperfusion did not reduce IS/AAR as assessed by histochemistry (cooling: 0.71 ± 0.8; control: 0.68 ± 0.10; p = ns) and SPECT (cooling: 0.90 ± 0.20; control: 0.88 ± 0.32; p = ns). Systemic hypothermia during ischemia reduced IS/AAR (histochemistry: 0.09 ± 0.11; SPECT: 0.25 ± 0.22; p < 0.001 and p = 0.01 vs control, respectively). Induction of systemic hypothermia during reperfusion had no significant effect on IS/AAR (histochemistry: 0.63 ± 0.07; SPECT: 0.74 ± 0.09; p = ns vs control for both comparisons). In conclusion, hypothermia during ischemia is strongly myocardioprotective while hypothermia during reperfusion does not reduce myocardial infarct size in human–sized pigs.


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