TITLE

Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study

AUTHOR(S)
Murray, C. D. R.; Martin, N. M.; Patterson, M.; Taylor, S. A.; Ghatei, M. A.; Kamm, M. A.; Johnston, C.; Bloom, S. R.; Emmanuel, A. V.
PUB. DATE
December 2005
SOURCE
Gut;Dec2005, Vol. 54 Issue 12, p1693
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Diabetic gastroparesis is a disabling condition with no consistently effective treatment. In animals, ghrelin increases gastric emptying and reverses postoperative ileus. We present the results of a double blind, placebo controlled, crossover study of ghrelin in gastric emptying in patients with diabetic gastroparesis. Methods: Ten insulin requiring diabetic patients (five men, six type I) referred with symptoms indicative of gastroparesis received a two hour infusion of either ghrelin (5 pmol/kg/min) or saline on two occasions. Blood glucose was controlled by euglycaemic clamp. Gastric emptying rate (GER) was calculated by real time ultrasound following a test meal. Blood was sampled for ghrelin, growth hormone (GH), and pancreatic polypeptide (PP) levels. Cardiovagal neuropathy was assessed using the Mayo Clinic composite autonomic severity score (range 0 (normal)-3). Results: Baseline ghrelin levels were mean 445 (SEM 36) pmol/l. Ghrelin infusion achieved a peak plasma level of 2786 (188) pmol/l at 90 minutes, corresponding to a peak GH of 70.9 (19.8) pmol/l. Ghrelin increased gastric emptying in seven of 10 patients (30 (6)% to 43 (5)%; p = 0.04). Impaired cardiovagal tone correlated inversely with peak postprandial PP values (p<0.05) but did not correlate with GER. Conclusions: Ghrelin increases gastric emptying in patients with diabetic gastroparesis. This is independent of vagal tone. We propose that analogues of ghrelin may represent a new class of prokinetic agents.
ACCESSION #
19160189

 

Related Articles

  • Prokinetic Effects of a New Ghrelin Receptor Agonist TZP-101 in a Rat Model of Postoperative Ileus. Kalina Venkova; Graeme Fraser; Hamid Hoveyda // Digestive Diseases & Sciences;Sep2007, Vol. 52 Issue 9, p2241 

    Abstract  Postoperative ileus (POI) is a major cause of postoperative complications and prolonged hospitalization. Ghrelin, which is the endogenous ligand for the growth hormone secretagogue receptor, has been found to stimulate gastric motility and accelerate gastric emptying....

  • Mealtime glucose regulation by nateglinide in type-2 diabetes mellitus. Walter, Y. H.; Spratt, D. I.; Garreffa, S.; McLeod, J. F. // European Journal of Clinical Pharmacology;May2000, Vol. 56 Issue 2, p129 

    Objectives: Pharmacodynamic effects of nateglinide, a novel antidiabetic agent, were investigated in patients with type-2 diabetes mellitus. Methods: Ten patients participated in this single-center, double-blind, crossover study. Plasma glucose and insulin levels were measured over 24 h...

  • Gemfibrozil considerably increases the plasma concentrations of rosiglitazone M. Niemi et al.: Interaction between gemfibrozil and rosiglitazone. Niemi, M.; Backman, J. T.; Granfors, M.; Laitila, J.; Neuvonen, M.; Neuvonen, P. J. // Diabetologia;Oct2003, Vol. 46 Issue 10, p1319 

    Aims/hypothesis. Our aim was to investigate possible interaction between gemfibrozil and rosiglitazone, a thiazolidinedione antidiabetic drug. Methods. In a randomised crossover study with two phases, 10 healthy volunteers took 600 mg gemfibrozil or placebo orally twice daily for 4 days. On day...

  • Inverse Relationship Exists between Ghrelin and Androgens in PCOS Women.  // Fertility Weekly;9/5/2005, p7 

    The article cites a study conducted by researcher D. Panidis and colleagues published in the 2005 issue of the journal "Human Reproduction" which compares plasma ghrelin levels in women with polycystic ovary syndrome (PCOS), women with hyperandrogenemia and healthy controls. In PCOS, circulating...

  • Plasma Levels of Total and Active Ghrelin in Acromegaly and Growth Hormone Deficiency. Jarkovská, Z.; Rosicka, M.; Marek, J.; Hána, V.; Weiss, V.; Justová, V.; Lacinová, Z.; Haluzík, M.; Kršek, M. // Physiological Research;2006, Vol. 55 Issue 2, p175 

    Ghrelin is an endogenous growth hormone (GH) secretagogue recently isolated from the stomach. Although it possesses a strong GH releasing activity in vitro and in vivo, its physiological significance in endogenous GH secretion remains unclear. The aim of this study was to characterize plasma...

  • Ghrelin expression in gut endocrine growths. Rindi, Guido; Savio, Antonella; Torsello, Antonio; Zoli, Michele; Locatelli, Vittorio; Cocchi, Daniela; Paolotti, Donatella; Solcia, Enrico // Histochemistry & Cell Biology;Jun2002, Vol. 117 Issue 6, p521 

    We aimed to assess the occurrence of ghrelin, a new gut hormone, in endocrine growths of the stomach. In addition, since ghrelin has been detected in other gut derivatives during adult and/or fetal life, we also studied endocrine tumours of the pancreas, intestine and lung. A specific serum...

  • Implantable Gastric Stimulator Does Not Prevent the Increase in Plasma Ghrelin Levels That Occurs With Weight Loss. Korner, Judith; Nandi, Anindita; Wright, Suzanne M.; Waitman, Jonathan; McMahon, Donald J.; Bessler, Marc; Aronne, Louis J. // Obesity (19307381);Oct2011, Vol. 19 Issue 10, p1935 

    The SHAPE (Screened Health Assessment and Pacer Evaluation) trial was a 24 month randomized multicenter placebo-controlled study to determine the efficacy of an implantable gastric stimulator (IGS) for weight loss. This report is an investigator-initiated sub-study at one site designed to assess...

  • Effect of NR-Salacia on post-prandial hyperglycemia: A randomized double blind, placebo-controlled, crossover study in healthy volunteers. Koteshwar, Pravina; Raveendra, Kadur Ramamurthy; Allan, Joseph Joshua; Goudar, Krishnagouda Shankargouda; Venkateshwarlu, Kudiganti; Agarwal, Amit // Pharmacognosy Magazine;Oct-Dec2013, Vol. 9 Issue 36, p344 

    Background: Salacia chinensis (S. chinensis) is widely distributed in India and Sri Lanka. Most of the species of genus Salacia are known to have effects on blood glucose levels; however, the effects of S. chinensis on glucose levels are seldom reported. Objective: To evaluate the oral...

  • Use of HbA1c in Predicting progression to Diabetes in French Men and Women. Droumaguet, Celine; Balkau, Beverley; Charles, Marie Aline; Eschwege, Eveline; Simon, Dominique; Caces, Emile; Tichet, Jean // Diabetes Care;Jul2006, Vol. 29 Issue 7, p1619 

    OBJECTIVE -- Early identification of subjects at high risk for diabetes is essential, and random HbA1c (A1C) may be more practical than fasting plasma glucose (FPG). The predictive value of A1C, in comparison to FPG, is evaluated for 6-year incident diabetes. RESEARCH DESIGN AND METHODS -- From...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics