TITLE

The effect of asbestosis on lung cancer risk beyond the dose related effect of asbestos atone

AUTHOR(S)
Reid, A.; de Klerk, N.; Ambrosini, G. L.; Olsen, N.; Pang, S. C.; Berry, G.; Musk, A. W.
PUB. DATE
December 2005
SOURCE
Occupational & Environmental Medicine;Dec2005, Vol. 62 Issue 12, p885
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aims: To determine if the presence of asbestosis is a prerequisite for lung cancer in subjects with known exposure to blue asbestos (crocidolite). Methods: Former workers and residents of Wittenoom with known amounts of asbestos exposure (duration, intensity, and time since first exposure), current chest x ray and smoking information, participating in a cancer prevention programme (n = 1988) were studied. The first plain chest radiograph taken at the time of recruitment into the cancer prevention programme was examined for radiographic evidence of asbestosis according to the UICC (ILO) classification. Cox proportional hazards modelling was used to relate asbestosis, asbestos exposure, and lung cancer. Results: Between 1990 and 2002 there were 58 cases of lung cancer. Thirty six per cent of cases had radiographic evidence of asbestosis compared to 12% of study participants. Smoking status was the strongest predictor of lung cancer, with current smokers (OR = 26.5, 95% CI 3.5 to 198) having the greatest risk. Radiographic asbestosis (OR =1.94, 95% CI 1.09 to 3.46) and asbestos exposure (OR = 1.21 per f/ml-year, 95% CI 1.02 to 1.42) were significantly associated with an increased risk of lung cancer. There was an increased risk of lung cancer with increasing exposure in those without asbestosis. Conclusion: In this cohort of former workers and residents of Wittenoom, asbestosis is not a mandatory precursor for asbestos related lung cancer. These findings support the hypothesis that it is the asbestos fibres per se that cause lung cancer, which can develop with or without the presence of asbestosis.
ACCESSION #
19142065

 

Related Articles

  • Hand protection: Preventing chemical exposures. Minter, Stephen G. // Occupational Hazards;Nov99, Vol. 61 Issue 11, p71 

    No abstract available.

  • The Skin and Occupational Diseases. Emmett, Edward A. // Archives of Environmental Health;May/Jun84, Vol. 39 Issue 3, p144 

    Reports the accessibility of the skin in the absorption of hazardous materials encountered in the workplace. Influences of percutaneous absorption; Development of occupational dermatoses; Need of analytic epidemiologic studies.

  • Crocidolite, Radiographic Asbestosis and Subsequent Lung Cancer. de Klerk, N. H.; Musk, A. W.; Glancy, J. J.; Pang, S. C.; Lund, H. G.; Olsen, N.; Hobbs, M. S. T. // Annals of Occupational Hygiene;1997 Inhaled Particles VIII, Vol. 41, p134 

    The article presents a study to assess the exposure-response correlation of lung cancer and crocidolite of Wittenoon crocidolite employees in Australia. It features results of the cohort research on the lung cancer cases of the 6910 crocidolite employees in the country until December 1994....

  • The Smoker and His Conscience.  // America;4/2/1960, Vol. 103 Issue 1, p9 

    The article focuses on the health hazards of cigarette smoking. It notes on the evidence that links the relationship of heavy cigarette smoking and lung cancer, strengthened by the tobacco involvement. Moreover, the involvement strengthened the indication of tobacco as the greatest killer...

  • Workplace Hazards to Women's Reproductive Health. Rice, Heidi Roeber; Baker, Beth A. // Minnesota Medicine;Sep2007, Vol. 90 Issue 9, p44 

    Women make up nearly half of Minnesota's workforce. Thus, many women, including those of reproductive age, are exposed to workplace hazards. These hazards may be chemical—toxicants such as heavy metals, pesticides, and endocrine disruptors; physical-the result of activities or proximity...

  • Protecting waste collectors all around the world. Frings-Dresen, M. // Occupational & Environmental Medicine;Dec2005, Vol. 62 Issue 12, p820 

    This article presents a commentary on the article "World at Work: Brazilian Ragpickers," by M.C. da Silva and his colleagues, published in the October 2005 issue of the journal "Occupational and Environmental Medicine." Waste collection is a necessary hygiene-related activity all around the...

  • Retention of asbestos fibres in lungs of workers with asbestosis, asbestosis and lung cancer, and mesothelioma in Asbestos township Loosereewanich, P.; Dufresne, C. M.; Begin, R.; Dufresne, A.; Masse, S.; Perrault, G. // Occupational & Environmental Medicine;Dec1996, Vol. 53 Issue 12, p801 

    No abstract available.

  • Is hazmat hazardous? Smith, S.L. // Occupational Hazards;May97, Vol. 59 Issue 5, p43 

    Discusses the medical surveillance study on the dangers faced by hazardous materials (hazmat) teams who respond to chemical spills. Examples of hazardous materials; Exposure of hazmat teams to significant levels of noise and pulmonary irritants.

  • RADON: A SPECIAL CASE IN RADIATION PROTECTION. Vanmarcke, H. // Radiation Protection Dosimetry;2008, Vol. 130 Issue 1, p76 

    The conversion conventions of ICRP 65 are based on equality of detriment, not on dosimetry. They are derived from epidemiological studies on miners by comparing the risk of having fatal lung cancer with the detriment associated with a unit of exposure in ICRP 60. Things have moved on since ICRP...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics