Birth Defects

August 1973
Journal of Learning Disabilities;Aug/Sep1973, Vol. 6 Issue 7, p439
Academic Journal
The article discusses the studies related to Lysergic Acid Diethyamide (LSD) and its hazards. One of the study report implicates LSD for a greatly increased rate of spontaneous abortions and birth defects. The other study suggests that it may disrupt the body's immune system by interfering with the production of antibodies. In a recent study, Jacobson and Berlin reported on 148 pregnancies in which exposure of the women and their consorts to LSD was ascertained prior to delivery. A much higher incidence of abnormalities was found than had been observed in any previous study. Of the 148 pregnancies observed in this group, 83 resulted in live births; eight of these 83 infants, nearly 10 percent, had major congenital defects and two died after birth. Jacobson and Berlin were unable to provide a definitive correlation of increased reproductive risk with LSD because most of the parents in the study also ingested other drugs prior to conception. Edward W. Voss, and his associates at the University of Illinois, Urbana, had reported that LSD inhibits the production of antibodies by cultured rabbit lymphoid cells. Voss's results are preliminary and their full significance is not yet clear. The only supportive evidence that such an effect might occur in vivo are limited observations that animals under the influence of LSD show a reduced responsiveness to antigens.


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