Biochemistry Migraine- Serotonin

May 1974
Journal of Learning Disabilities;May1974, Vol. 7 Issue 5, p295
Academic Journal
This article presents information on the role of serotonin precursors in migraine biochemistry. A new theory has been proposed for the interpretation of the headache mechanism, in the form of an evolution of the serotonin pathogenesis. According to the migraine-headache serotonin theory (supersensitivity from monoamine deficiency), 5-hydroxytryptophan and tryptophan have been administered to migraine sufferers and the effect was compared with that of a proven migraine preventative agent. Results of this preliminary study conducted in Rome, Italy, indicated that the ingestion of serotonin precursors (L-5-Hydroxytryptophan and L-Tryptophan) improves migraine-headache. Its efficiency appears statistically similar to that of methysergide.


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