TITLE

Gemcitabine, vinorelbine and prednisone for refractory or relapsed aggressive lymphoma,results of a phase II single center study

AUTHOR(S)
Müller-Beißenhirtz, Hannes; Kasper, Christoph; Nückel, Holger; Dührsen, Ulrich
PUB. DATE
December 2005
SOURCE
Annals of Hematology;Dec2005, Vol. 84 Issue 12, p796
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The optimum therapy for patients with relapsed or refractory aggressive non-Hodgkin’s lymphomas (NHL) not qualifying for platinum-based and/or high-dose chemotherapy is not known. We conducted a prospective phase II study evaluating a regimen consisting of gemcitabine (1 g/m2, days 1 and 8), vinorelbine (30 mg/m2, days 1 and 8) and prednisone (100 mg/day, days 1–8) (GVP) given every 21 days. Fifteen patients with a median age of 68 years and a median of three previous therapies were enrolled. Diagnoses included B lymphoblastic ( n=1), diffuse large B cell ( n=10), anaplastic large T cell ( n=2) and peripheral T-cell NHL ( n=2). The median international prognostic index score was 3 (six patients with a score of 4 or 5). Five patients achieved a complete remission and three patients a partial remission. The median overall survival was 13.8 months, and the median time to next treatment was 4.4 months. Haematological toxicities of World Health Organisation grades 3/4 were leucopenia in 58%, thrombocytopenia in 33% and anaemia in 17% of all courses. Three patients had grade 3 infections. There was no treatment-related mortality. GVP shows substantial activity in poor prognosis relapsed or refractory aggressive lymphomas and is generally well tolerated, but haematological toxicity is dose limiting.
ACCESSION #
19095540

 

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