TITLE

Complement profile in childhood immune thrombocytopenic purpura: a prospective pilot study

AUTHOR(S)
Ohali, Meli; Maizlishi, Yair; Abramov, Haya; Schlesinger, Menachem; Bransky, David; Lugassy, Gilles
PUB. DATE
December 2005
SOURCE
Annals of Hematology;Dec2005, Vol. 84 Issue 12, p812
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Immune thrombocytopenic purpura (ITP) is a frequent, usually acute hematologic complication of viral diseases in children. Its evolution is usually benign with spontaneous resolution. Some authors have raised the hypothesis of a possible role of the complement system in the pathogenesis of ITP. In the present study, we measured the complement system components in 25 children with ITP. The complement system was abnormal in most patients with ITP as compared with the control group: 20 of the 25 patients had at least one low-component level. The most affected components were properdin, factor H ( p=0.005 and p=0.001, respectively), C1q, C9, and factor B. Our results may indicate a possible role for the complement system in the pathogenesis of pediatric ITP.
ACCESSION #
19095537

 

Related Articles

  • Predictors of chronic thrombocytopenia purpura in children.  // Nursing Standard;4/23/2008, Vol. 22 Issue 33, p17 

    The article reports on the move of researchers to investigate risk factors for developing the idiopathic thrombocytopenic purpura (ITP) using a retrospective analysis of a cohort of 250 children in the U.S. Of the 259 cases, 197 were acute, 60 were chronic and two could not be determined....

  • Romiplostim use in ITP. Lohr, Lisa // Hem/Onc Today;12/25/2008, Vol. 9 Issue 23, p13 

    The article discusses the use of romiplostim in the treatment of immune thrombocytopenia or idiopathic thrombocytopenic purpura (ITP). ITP is a syndrome characterized by accelerated platelet destruction. Romiplostim is a recombinant protein that stimulates platelet production by binding to and...

  • Purpura Factitia. White, James G.; Pearson, Howard A.; Coddington, R. Dean // Clinical Pediatrics;Mar1966, Vol. 5 Issue 3, p157 

    Describes a nine-year-old girl whose purpura factitia developed during or immediately after recovery from a probable attack of idiopathic thrombocytopenia purpura. Suggested mechanism for this unusual symptom complex; Analysis of pertinent topics and relevant issues; Implications on pediatrics.

  • Chronic, Episodic Thrombocytopenia. McClain, Kenneth L. // Clinical Pediatrics;Mar1990, Vol. 29 Issue 3, p179 

    A male patient with chronic idiopathic thrombocytopenic purpura (ITP) did not fit into any of the known risk groups for chronic ITP. He was unique in that he manifested a cyclic increase of platelet counts each winter followed by a nadir in the summer, without having other hematologic abnormalities.

  • Análisis de 200 casos clínicos de púrpura trombocitopénica idiopática. García-Stivalet, Lilia Adela; Muñoz-Flores, Aarón; Montiel-Jarquín, Álvaro José; Barragán-Hervella, Rodolfo Gregorio; Bejarano-Huertas, Ruth; García-Carrasco, Mario; López-Colombo, Aurelio // Revista Medica del IMSS;jul-ago2014, Vol. 52 Issue 4, p322 

    Background: Idiopathic thrombocytopenic purpura is characterized by extravasation of blood into the subcutaneous tissue, mucous membranes or skin; it generates bleeding manifestations as ecchymotic lesions, petechiae of sudden onset, epistaxis, bleeding from the gums, and serious complications...

  • Life-threatening spontaneous hemothorax in a patient with thrombotic thrombocytopenic purpura. KUBOTA, TAKESHI; KOIZUMI, SEIJI; MIYATA, AKIMASA; HAMADA, WAICHIROU // Journal of Anesthesia;2009, Vol. 23 Issue 1, p129 

    Spontaneous hemothorax in the left pleural space occurred suddenly in a patient with thrombotic thrombocytopenic purpura (TTP). In spite of massive blood transfusion, the hemorrhage could not be stopped. The patient suffered shock due to tension hemothorax and hypovolemia, resulting in cardiac...

  • Thrombocytopenic Purpura. Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p638 

    An encyclopedia entry for thrombocytopenic purpura is presented. It is a rare autoimmune disorder characterized by a shortage of platelets. This leads to bruising and spontaneous bleeding. Most of the cases are idiopathic while others are caused by drugs, infections or autoimmune disorders such...

  • Onyalai (A Form of Idiopathic Thrombocytopenic Purpura) in the United States. Harris, Michael B.; Murphy, Scott; Oski, Frank A. // Clinical Pediatrics;Dec1972, Vol. 11 Issue 12, p705 

    Cites a case of Onyalai, a form of idiopathic thrombocytopenic purpura in the U.S. Application of the term to a thrombocytopenic syndrome characteristics by the presence of hemorrhagic bullas of the buccal mucosa and lips; Clinical features of more common form of acute idiopathic...

  • High-dose dexamethasone as a first- and second-line treatment of idiopathic thrombocytopenic purpura in adults. Borst, F.; Keuning, J.J.; van Hulsteijn, H.; Sinnige, H.; Vreugdenhil, G. // Annals of Hematology;Dec2004, Vol. 83 Issue 12, p764 

    The current first-line choice of treatment of idiopathic thrombocytopenic purpura (ITP) in adults, prednisone, is effective but has many side effects. Furthermore, reduction of the dose leads to a relapse of ITP in a majority of cases. Courses of high-dose dexamethasone (HD) aim to avoid these...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics