Combination antibiotic susceptibility testing in CF: disappointing clinical results

Holme, J.
November 2005
Thorax;Nov2005, Vol. 60 Issue 11, p915
Academic Journal
The article presents the clinical results of antibiotic susceptibility testing in cystic fibrosis (CF). Patients with CF are often colonized with multiresistant organisms. In vitro data suggest that bactericidal activity might result from antibiotic synergy even if species are resistant to individual agents on routine resistance testing. This multicenter, prospective, double blind, randomized controlled trial investigated the in vivo effects of selecting antibiotics for exacerbations of CF, based on MCBT versus conventional sensitivity testing. Sputum was tested every 3 months for up to 4 years from 251 patients with CF over 12 years of age who were chronically infected with multiresistant organisms. Both testing methods were used for each sample. Using the results, combinations of two antibiotics with or without nebulised tobramycin were recommended by two separate investigators--one using the MCBT results and the other the conventional sensitivity results.


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