South African GB Virus C Isolates: Interactions between Genotypes 1 and 5 Isolates and HIV

Jinhua Xiang; Sathar, M. Aslam; McLinden, James H.; Klinzman, Donna; Qing Chang; Stapleton, Jack T.
December 2005
Journal of Infectious Diseases;12/15/2005, Vol. 192 Issue 12, p2147
Academic Journal
GB virus C (GBV-C) is a common, apparently nonpathogenic human flavivirus that has been associated in some studies with prolonged survival in human immunodeficiency virus (HIV)-positive persons. There are 5 distinct GBV-C genotypes localized to specific geographic regions, and genotype 2 has been previously shown to inhibit HIV replication in vitro in lymphocyte cultures. We identified GBV-C virus isolates representing genotypes 1, 2, and 5 in samples from South African blood donors. GBV-C genotype 1 and 5 isolates replicated in lymphocyte culture, inhibited X4 and R5 HIV- 1 isolates, and induced RANTES and stromal-derived factor- 1 chemokines in vitro. Thus, African GBV-C genotypes can inhibit HIV replication in vitro.


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