TITLE

Diphtheria with polyneuropathy in a closed community despite receiving recent booster vaccination

AUTHOR(S)
Krumina, A.; Logina, I.; Donaghy, M.; Rozentale, B.; Kravale, I.; Griskevica, A.; Viksna, L.
PUB. DATE
November 2005
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Nov2005, Vol. 76 Issue 11, p1555
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Introduction and Methods: We report 20 patients aged 18-24 years from Latvia with diphtheritic polyneuropathy. All lived in a closed community and 80% were known to have been fully vaccinated against diphtheria until at least 14 years old. Diphtheria antitoxin had been administered within 3 days of the onset of upper respiratory tract infection in 16 patients and 15 received antibiotics.Results: Neurological symptoms developed after a median of 43 days (range 35-58) compared to only 10 days in previous studies of unvaccinated patients. All showed evidence of mild limb polyneuropathy with electrophysiological evidence of polyneuropathy. Only 30% showed early bulbar abnormalities compared to the usual rate of over 95% in diphtheritic polyneuropathy. However, 45% had later bulbar deterioration coinciding with the limb polyneuropathy.Conclusions: These patients show that an attenuated form of polyneuropathy of later onset, with less prominent early bulbar features, can occur in patients vaccinated against diphtheria according to schedule but living in a closed community in a country where diphtheria remains endemic.
ACCESSION #
18972065

 

Related Articles

  • Diphtheria Vaccine Immunity in Patients with Type 1 Diabetes Mellitus. Dursun, Hasan; Cinaz, Peyami; Bideci, Aysun; Aybay, Cemalettin // Istanbul Medical Journal;2014, Vol. 15 Issue 1, p21 

    Objective: Patients with Type 1 diabetes mellitus (DM) may have abnormalities in immune function and presumed increased morbidity and mortality from infections. The aim of this study was to compare the diphtheria antitoxin levels in immunized children with Type 1 DM and healthy children....

  • The enemy on the ground. Ainsworth, Steve // Practice Nurse;11/19/2010, Vol. 40 Issue 9, p36 

    The article offers a discussion on diphtheria, the common cause of death in children. The disease commonly affects the nose and throat and may affect the skin. High temperature, sore throat, and breathing difficulties are the symptoms of diphtheria. The toxoid, an inactivated toxin, is the...

  • Effect of a Diphtheria Booster Vaccination in Adults with a Documented History of an Incomplete Primary Series Vaccination. Hasselhorn, H.; Hofmann, F.; Nubling, M. // Infection;Oct2004, Vol. 32 Issue 5, p282 

    Background: An incomplete series of diphtheria vaccination is frequently found in the vaccination documents of adult patients. This paper investigates the effect of a booster vaccination in adults with an incomplete series of primary vaccination. Materials and Methods: The effect of one...

  • Fault Tolerant Mobile Sensor Node Traversal Schemes Based on Hexagonal Coverage. Santoshi, Ganala; D'Souza, R. J. // Scientific World Journal;2014, p1 

    No abstract available.

  • Diphtheria vaccine.  // Weekly Epidemiological Record;1/20/2006, Vol. 81 Issue 3, p24 

    The article presents information on diphtheria vaccine. Exotoxin-producing Gorynebacterium diphtheriae causes diphtheria. A modified bacterial toxin inducing protective antitoxin called diphtheria toxoid forms the basis of diphtheria vaccines. In the World Health Organization Expanded Programme...

  • Case-Control Evaluation of an Adult Diphtheria Immunization Program in Ukraine. Tsu, Vivien; Tyshchenko, Dmytro K. // Journal of Infectious Diseases;2/15/2000 Supplement 1, Vol. 181, pS188 

    Examines the efficacy of a diphtheria immunization program for adults in Ukraine in 1996. Difference of potency compared with the vaccines developed from Western countries; Determination of the treatment rates.

  • Implications of the Diphtheria Epidemic in the Former Soviet Union for Immunization Programs. Galazka, Artur // Journal of Infectious Diseases;2/15/2000 Supplement 1, Vol. 181, pS244 

    Comments on the impact of diphtheria vaccination practices in the former Soviet Republics on immunization programs in other countries. Studies needed to elaborate the most effective strategy to maintain immunity; Importance of adopting efforts to monitor diphtheria immunity in different groups.

  • Side Effects of Diptheria-Tetanus Toxoid in Adults . Middaugh, John P. // American Journal of Public Health;Mar1979, Vol. 69 Issue 3, p246 

    Abstract: During a mass diphtheria-tetanus immunization campaign in November 1975, more than 220,000 doses of diphtheria-tetanus toxoid, adult type were administered to adults throughout Alaska. In Anchorage, where more than 87,000 doses were given, a survey was conducted to determine the...

  • Diphtheria Outbreak in Haiti, 2009.  // Immunization Newsletter;2009, Vol. 31 Issue 6, p1 

    The article discusses the outbreak of diphtheria infection in Haiti in 2009. It stresses that in August 2009, 33 cases of the infectious disease were reported with 45% case fatality rate. It mentions that disease management and containment measures which include vaccinations were implemented...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics