Biochemistry -- Metabolic Disorders

McGlannan, Frances
June 1974
Journal of Learning Disabilities;Jun/Jul1974, Vol. 7 Issue 6, p361
Academic Journal
This article reports that man has lost the ability to synthesize each of the vitamin molecules, but he has retained a complex set of reactions needed for normal vitamin use. These reactions include systems for intestinal absorption, transport in plasma, entry into tissue cells, subcellular compartmentation, activation of vitamin in coenzyme, and interaction with specific apoenzyme proteins. This study indicates that a short course of vitamins in large amounts represents a valuable therapeutic trial in patients with neurologic or psychiatric problems of unknown nature. However, tong-term, uncritical use of pharmacologic dosages of vitamins must be avoided. About 25 different vitamin-responsive inherited metabolic diseases are recognized, and the list is growing rapidly. Disorders responsive to both fat- and water-soluble vitamins have been identified. Clinical manifestations vary from none to lethal and many organ systems have been involved.


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