EEG -- Infantile Spasms

McGlannan, Frances; Watanabe, Kazuyoshi; Iwase, Katsuhiko; Hara, Kimiko
April 1974
Journal of Learning Disabilities;Apr1974, Vol. 7 Issue 4, p212
Academic Journal
This article reports on a study which described the developmental course of infantile spasms and hypsarrhythmia. It has been generally accepted that infantile spasms are not a disease entity, but are an age-specific response of the infant brain, and that the characteristic electroencephalographic (EEG) abnormality disappears with maturation. Thirty-two infants who had been examined before the onset of infantile spasms were the subjects. They were divided into three groups according to their possible etiology. The prenatal group consisted of 17 infants in whom prenatal etiology was suspected or no possible causes were found. All these infants had a normal perinatal history and there was no obvious postnatal cause for the spasms. The perinatal group consisted of eight infants who suffered from perinatal hypoxic brain injury and later developed infantile spasms. Serial EEG and neurological examinations were made, besides general pediatric and laboratory examination. Initial convulsive seizures were treated with ordinary anti-convulsants and when infantile spasms developed they were treated with ACTH-Z or nitrazepam. In this study, special emphasis was placed on the evolutionary changes of EEG features up to the onset of the spasms.


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