Efficacy of intensive multitherapy for patients with type 2 diabetes mellitus: a randomized controlled trial

Ménard, Julie; Payette, Hélène; Baillargeon, Jean-Patrice; Maheux, Pierre; Lepage, Serge; Tessier, Daniel; Ardilouze, Jean-Luc
December 2005
CMAJ: Canadian Medical Association Journal;12/6/2005, Vol. 173 Issue 12, p1457
Academic Journal
Background National guidelines for managing diabetes set standards for care. We sought to determine whether a 1-year intensive multitherapy program resulted in greater goal attainment than usual care among patients with poorly controlled type 2 diabetes mellitus. Methods We identified patients with poorly controlled type 2 diabetes receiving outpatient care in the community or at our hospital. Patients 30-70 years of age with a hemoglobin A1c concentration of 8% or greater were randomly assigned to receive intensive multitherapy (n = 36) or usual care (n = 36). Results The average hemoglobin A1c concentration at entry was 9.1% (standard deviation [SD] 1%) in the intensive therapy group and 9.3% (SD 1%) in the usual therapy group. By 12 months, a higher proportion of patients in the intensive therapy group than in the control group had achieved Canadian Diabetes Association (CDA) goals for hemoglobin A1c concentrations (goal ≤ 7.0%: 35% v. 8%), diastolic blood pressure...


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