Review: Computed tornographic colonography has high specificity but low-to-moderate sensitivity for detecting colorectal polyps: COMMENTARY

Bhutani, Manoop S.; Pasricha, P. Jay
November 2005
ACP Journal Club;Nov/Dec2005, Vol. 143 Issue 3, p78
Academic Journal
This article comments on a clinical study according to which computed tornographic colonography has high specificity but low-to-moderate sensitivity for detecting colorectal polyps. Unlike many other malignant tumors, colorectal cancer is preventable by detection and removal of precancerous adenomas. In the meta-analysis, the sensitivity of CTC was clearly unacceptable. However, the analysis was limited by the heterogeneity of the studies across many parameters, including patient risk status, method of colonoscopic analysis, mode of imaging and reconstruction, and type of scanner and software used. Currently, this technique costs about $3600 more per life-year saved than conventional colonoscopy, a figure that will also change with the evolving technology.


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