An immediate antiepileptic drug regimen reduced short-term (2-y) recurrence of seizures more than a deferred regimen: COMMENTARY

Wiebe, Samuel
November 2005
ACP Journal Club;Nov/Dec2005, Vol. 143 Issue 3, p75
Academic Journal
This article comments on a clinical study according to which an immediate antiepileptic drug (AED)regimen reduced short-term recurrence of seizures more than a deferred regimen. In a very diverse group of patients, with equally diverse risks for seizure recurrence, researchers compared early and deferred AED treatment after a first seizure or an early diagnosis of epilepsy. The more common occurrence of status epilepticus and deaths in the early-treatment group is unexpected and paradoxical however, the relatively infrequent occurrence precludes drawing valid statistical inferences. The possibility of somewhat sicker patients in the early-treatment group comes to mind, but chance alone could explain this finding.


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