TITLE

Review: α-Glucosidase inhibitors improve glycemic control but have uncertain effects on patient-important outcomes in type 2 diabetes: COMMENTARY

AUTHOR(S)
Isley, William L.
PUB. DATE
November 2005
SOURCE
ACP Journal Club;Nov/Dec2005, Vol. 143 Issue 3, p66
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article comments on a clinical study according to which glucosidase inhibitors improve glycemic control but have uncertain effects on patient-important outcomes in type 2 diabetes. α-Glucosidase inhibitors are sparsely used in the U.S. compared with some other countries because of their modest efficacy and untoward gastrointestinal side effects, particularly "hyperflatulence." α-Glucosidase inhibitors produce very modest improvements in glycemic control, primarily affecting postprandial glucose excursions. The problematic side effects and limited efficacy of α-glucosidase inhibitors make them unlikely to be a mainstay of diabetic therapy. This view has been voiced in official public pronouncements in Europe.
ACCESSION #
18925740

 

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