TITLE

Review: Tiotropium reduces exacerbations and hospitalizations in COPD and improves quality of life

PUB. DATE
November 2005
SOURCE
ACP Journal Club;Nov/Dec2005, Vol. 143 Issue 3, p59
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article presents information on a clinical study according to which tiotropium reduces exacerbations and hospitalizations in chronic obstructive pulmonary disease (COPD) and improves quality of life. Randomized controlled trials in any language that included patients less than 35 years of age with known stable COPD without evidence of an exacerbation for 1 month before study entry, and compared tiotropium with placebo, ipratropium bromide, or long-acting β-agonists for ≥ 1 month. Studies of patients with diseases other than COPD, previous asthma, cystic fibrosis, bronchiectasis, or other lung diseases were excluded. Exacerbations, hospitalizations for exacerbations, and all-cause mortality.
ACCESSION #
18925725

 

Related Articles

  • Pulmatrix Hastens COPD Trials Via $14M Series B1 Financing. Boggs, Jennifer // BioWorld Today;8/16/2011, Vol. 22 Issue 158, p1 

    The article discusses trials in chronic obstructive pulmonary disease (COPD) and cystic fibrosis being conducted by Pulmatrix Inc. as it accelerates its development of PUR118. It cites its progress in converting its inhaled cationic airway lining modulator (iCALM) program from liquid...

  • cystic fibrosis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p567 

    An encyclopedia entry for "cystic fibrosis," is presented. Cystic fibrosis is an autosomal recessive disease that is potentially fatal. The disease can manifest itself in many body systems such as the lungs, the pancreas and the skeleton. It can cause chronic obstructive pulmonary disease,...

  • Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease. Hartl, Dominik; Latzin, Philipp; Hordijk, Peter; Marcos, Veronica; Rudolph, Carsten; Woischnik, Markus; Krauss-Etschmann, Susanne; Koller, Barbara; Reinhardt, Dietrich; Roscher, Adelbert A; Roos, Dirk; Griese, Matthias // Nature Medicine;Dec2007, Vol. 13 Issue 12, p1423 

    Interleukin-8 (IL-8) activates neutrophils via the chemokine receptors CXCR1 and CXCR2. However, the airways of individuals with cystic fibrosis are frequently colonized by bacterial pathogens, despite the presence of large numbers of neutrophils and IL-8. Here we show that IL-8 promotes...

  • Cystic fibrosis lung disease: genetic influences, microbial interactions, and radiological assessment. Moskowitz, Samuel M.; Gibson, Ronald L.; Effmann, Eric L. // Pediatric Radiology;Aug2005, Vol. 35 Issue 8, p739 

    Cystic fibrosis (CF) is a multiorgan disease caused by mutation of the CF transmembrane conductance regulator (CFTR) gene. Obstructive lung disease is the predominant cause of morbidity and mortality; thus, most efforts to improve outcomes are directed toward slowing or halting lung-disease...

  • New Test for Lung Disorder. Uehling, Mark D. // Bio-IT World;Aug2004, Vol. 3 Issue 8, p14 

    Reports on a project by Laboratory Corporation of America which aimed to develop a DNA test for the risk factor that leads to chronic obstructive pulmonary disease. Effect of &alpha[sub1[-antitrypsin deficiency (ATT); Significance of a cystic fibrosis test to the ATT project.

  • The CFTR frameshift mutation 3905insT and its effect at transcript and protein level. Sanz, Javier; von Känel, Thomas; Schneider, Mircea; Steiner, Bernhard; Schaller, André; Gallati, Sabina // European Journal of Human Genetics;Feb2010, Vol. 18 Issue 2, p212 

    Cystic fibrosis (CF) is one of the most common genetic diseases in the Caucasian population and is characterized by chronic obstructive pulmonary disease, exocrine pancreatic insufficiency, and elevation of sodium and chloride concentrations in the sweat and infertility in men. The disease is...

  • Significance of Recurrent Hemoptysis in Allergic Asthma. Marks, Meyer B. // Clinical Pediatrics;Aug1971, Vol. 10 Issue 8, p479 

    This article presents information on a case study related to recurrent hemoptysis in allergic asthma. Children who aspirate foreign bodies may wheeze. Often the breath sounds are transmitted throughout the lung fields. Researchers H.E. Williams and P.D. Phelan studied 189 children who had...

  • LUNG CLEARANCE INDEX (LCI) IN CHILDREN WITH SEVERE, THERAPY RESISTANT ASTHMA (STRA). Irving, S.; Bush, A.; Bossley, C.; Gupta, A.; Saglani, S. // Thorax;Dec2011 Supplement, pA99 

    Introduction Spirometry is often normal in children with STRA, and is thus a poor outcome measure (1). Lung Clearance Index is a sensitive, non-effort dependent measure of distal airway gas mixing, which has been shown to be more sensitive than spirometry in Cystic Fibrosis (2). We hypothesised...

  • Unravelling salt transport in cystic fibrosis. Noone, P. G.; Southern, K. W. // Thorax;Nov2004, Vol. 59 Issue 11, p916 

    This article presents information related to salt transport in cystic fibrosis (CF). CF is characterized by thick viscid air-way secretions, the development of progressive airways obstruction and bronchiectasis. In patients with CF, the magnitude of sodium absorption across airway epithelia and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics