Review: Tiotropium reduces exacerbations and hospitalizations in COPD and improves quality of life

November 2005
ACP Journal Club;Nov/Dec2005, Vol. 143 Issue 3, p59
Academic Journal
This article presents information on a clinical study according to which tiotropium reduces exacerbations and hospitalizations in chronic obstructive pulmonary disease (COPD) and improves quality of life. Randomized controlled trials in any language that included patients less than 35 years of age with known stable COPD without evidence of an exacerbation for 1 month before study entry, and compared tiotropium with placebo, ipratropium bromide, or long-acting β-agonists for ≥ 1 month. Studies of patients with diseases other than COPD, previous asthma, cystic fibrosis, bronchiectasis, or other lung diseases were excluded. Exacerbations, hospitalizations for exacerbations, and all-cause mortality.


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