TITLE

Review: Chemotherapy and hormonal therapy reduce recurrence and mortality at 15 years in early breast cancer

PUB. DATE
November 2005
SOURCE
ACP Journal Club;Nov/Dec2005, Vol. 143 Issue 3, p58
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This article presents information on a clinical study which found that chemotherapy and hormonal therapy reduce recurrence and mortality at 15 years in early breast cancer. Unconfounded randomized controlled trials (RCTs) of adjuvant systemic therapies for early breast cancer begun before 1995. Individual patient data and updated follow-up were sought on every woman included in the studies. Main outcomes were death from breast cancer, death from other causes, breast cancer recurrence, and incidence of second cases of cancer. 194 RCTs were included and comprise about 91% of all women randomized in such trials before 2000. Adjuvant chemotherapy, tamoxifen, and ovarian ablation or suppression substantially reduce mortality rates over 15 years in women with early breast cancer.
ACCESSION #
18925723

 

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