TITLE

Improved Sperm Chromatin Dispersion Test Is Efficacious

PUB. DATE
November 2005
SOURCE
Fertility Weekly;11/14/2005, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article cites a study conducted by researcher J.L. Fernandez and colleagues, published in the 2005 issue of the journal "Fertility & Sterility," regarding the sperm chromatin dispersion (SCD) test and its development as a simple kit for determination of sperm DNA fragmentation. According to a report from Spain and the United States, the improved sperm chromatin dispersion test is effective and reliable for evaluating human sperm DNA fragmentation. The researchers developed a new and improved SCD test, the Halosperm kit, and used it to analyze sperm samples from nine fertile men, 46 normozoospermic patients, 23 oligoasthenoteratozoospermic patients, and a man with varicocele.
ACCESSION #
18922238

 

Related Articles

  • Sperm chromatin structure and male fertility: biological and clinical aspects. Erenpreiss, J.; Spano, M.; Erenpreisa, J.; Bungum, M.; Giwercman, A. // Asian Journal of Andrology;Jan2006, Vol. 8 Issue 1, p11 

    Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not...

  • Cytometry of chromatin bound Mcm6 and PCNA identifies two states in G1 that are separated functionally by the G1 restriction point1. Frisa, Phyllis S.; Jacobberger, James W. // BMC Cell Biology;2010, Vol. 11, p26 

    Background: Cytometric measurements of DNA content and chromatin-bound Mcm2 have demonstrated bimodal patterns of expression in G1. These patterns, the replication licensing function of Mcm proteins, and a correlation between Mcm loading and cell cycle commitment for cells re-entering the cell...

  • MDC1: The art of keeping things in focus. Jungmichel, Stephanie; Stucki, Manuel // Chromosoma;Aug2010, Vol. 119 Issue 4, p337 

    The chromatin structure is important for recognition and repair of DNA damage. Many DNA damage response proteins accumulate in large chromatin domains flanking sites of DNA double-strand breaks. The assembly of these structures—usually termed DNA damage foci—is primarily regulated...

  • Correlation Exists between Sperm Head Strict Morphology and High DNA Stainability.  // Fertility Weekly;12/14/2009, p3 

    The article examines the correlation of sperm head morphology with high DNA stainability. Researchers in Canada have said that sperm head abnormalities may be due to incomplete sperm chromatin condensation as an inverse relationship exists between its morphology and high DNA stainability....

  • Sperm-derived histones contribute to zygotic chromatin in humans. van der Heijden, Godfried W.; Ramos, Liliana; Baart, Esther B.; van den Berg, Ilse M.; Derijck, Alwin A. H. A.; van der Vlag, Johan; Martini, Elena; de Boer, Peter // BMC Developmental Biology;2008, Vol. 8, Special section p1 

    Background: about 15% to 30% of the DNA in human sperm is packed in nucleosomes and transmission of this fraction to the embryo potentially serves as a mechanism to facilitate paternal epigenetic programs during embryonic development. However, hitherto it has not been established whether these...

  • Evaluation of Gram Stain as an Alternative in the Assessment of Human Spermatozoa Quality. Mantas, D.; Msaouel, P.; Angelopoulou, R. // Urologia Internationalis;Jan2006, Vol. 76 Issue 1, p57 

    Introduction: During spermiogenesis, protaminosis and sperm chromatin condensation are important prerequisites for the preservation of DNA integrity in spermatozoa. The aim of this study is to assess Gram stain as an alternative technique for the evaluation of human sperm chromatin condensation...

  • The telomeric region is excluded from nucleosomal fragmentation during apoptosis, but the bulk nuclear chromatin is randomly degraded. Schliephacke, T.; Meini, A.; Kratzmeier, M.; Doenecke, D.; Albig, W. // Cell Death & Differentiation;Jul2004, Vol. 11 Issue 7, p693 

    Characteristic steps during cellular apoptosis are the induction of chromatin condensation and subsequent DNA fragmentation, finally leading to the formation of oligomers of nucleosomes. We have examined the kinetics and local distribution of this nucleosomal fragmentation within different...

  • XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Malorano, Domenico; Moreau, Jacques // Nature;4/6/2000, Vol. 404 Issue 6778, p622 

    Presents evidence that the protein XCDT1 is required for chromosomal DNA replication. Identification of XCDT1 in pre-replication complexes in maternally expressed genes in Xenopus; Similarity for XCDT1 to the fission yeast cdt1; Association of the protein with pre-replicative chromatin; Removal...

  • Chromatin fiber functional organization: Some plausible models. Lesne, A.; Victor, J.-M. // European Physical Journal E -- Soft Matter;Mar2006, Vol. 19 Issue 3, p279 

    We here present a modeling study of the chromatin fiber functional organization. Multi-scale modeling is required to unravel the complex interplay between the fiber and the DNA levels. It suggests plausible scenarios, including both physical and biological aspects, for fiber condensation, its...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics