TITLE

Amplification of Plasmodium falciparum Multidrug Resistance Gene 1 in Isolates from Gabon

AUTHOR(S)
Uhlemann, Anne-Catrin; Ramharter, Michael; Lell, Bertrand; Kremsner, Peter G.; Krishna, Sanjeev
PUB. DATE
November 2005
SOURCE
Journal of Infectious Diseases;11/15/2005, Vol. 192 Issue 10, p1830
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The study of molecular markers of drug resistance is particularly important in surveillance studies of drugs, such as mefloquine, that still retain efficacy in sub-Saharan Africa yet have encountered resistance elsewhere. In a recent study in Thailand, we identified amplification of the Plasmodium falciparum multidrug resistance gene 1 (pfmdr1) as being the most important predictor of in vitro drug resistance and in vivo failure of mefloquine monotherapy. Here we report amplification of pfmdr1 in >5% of patient samples from Lambaréné, Gabon, collected in 1995. None of the samples collected 7 years later showed pfmdr1 amplification, suggesting that parasites with increased numbers of pfmdr1 copies have not substantially spread through the population. Nevertheless, the detection of multicopy pfmdr1 in African parasites suggests a high potential for rapid selection for resistance, implying that mefloquine use in Africa should be considered only as part of combination therapy.
ACCESSION #
18911464

 

Related Articles

  • Real-Time Polymerase Chain Reaction Assay for the Rapid Detection and Characterization of Chloroquine-Resistant Plasmodium falciparum Malaria in Returned Travelers. Farcas, Gabriella A.; Soeller, Rainer; Zhong, Kathleen; Zahirieh, Alireza; Kain, Kevin C. // Clinical Infectious Diseases;3/1/2006, Vol. 42 Issue 5, p622 

    Background. Imported drug-resistant malaria is a growing problem in industrialized countries. Rapid and accurate diagnosis is essential to prevent malaria-associated mortality in returned travelers. However, outside of a limited number of specialized centers, the microscopic diagnosis of malaria...

  • Randomized Comparison of Amodiaquine plus Sulfadoxine-Pyrimethamine, Artemether-Lumefantrine, and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Burkina Faso. Zongo, Issaka; Dorsey, Grant; Rouamba, Noel; Dokomajilar, Christian; Séré, Yves; Rosenthal, Philip J.; Ouédraogo, Jean Bosco // Clinical Infectious Diseases;12/1/2007, Vol. 45 Issue 11, p1453 

    Background. Combination antimalarial therapy is advocated to improve treatment efficacy and limit selection of drug-resistant parasites. We compared the efficacies of 3 combination regimens in Bobo-Dioulasso, Burkina Faso: amodiaquine plus sulfadoxine-pyrimethamine, which was recently shown to...

  • Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Dae-Kyun Ro; Paradise, Eric M.; Ouellet, Mario; Fisher, Karl J.; Newman, Karyn L.; Ndungu, John M.; Ho, Kimberly A.; Eachus, Rachel A.; Ham, Timothy S.; Kirby, James; Chang, Michelle C. Y.; Withers, Sydnor T.; Shiba, Yoichiro; Sarpong, Richmond; Keasling, Jay D. // Nature;4/13/2006, Vol. 440 Issue 7086, p940 

    Malaria is a global health problem that threatens 300–500 million people and kills more than one million people annually. Disease control is hampered by the occurrence of multi-drug-resistant strains of the malaria parasite Plasmodium falciparum. Synthetic antimalarial drugs and malarial...

  • Dose-Dependent Risk of Neutropenia after 7-Day Courses of Artesunate Monotherapy in Cambodian Patients with Acute Plasmodium falciparum Malaria. Bethell, Delia; Youry Se; Lon, Chanthap; Socheat, Duong; Saunders, David; Teja-Isavadharm, Paktiya; Khemawoot, Phisit; Darapiseth, Sea; Lin, Jessica; Sriwichai, Sabaithip; Kuntawungin, Worachet; Surasri, Sittidech; Lee, Sue J.; Sarim, Ses; Tyner, Stuart; Smith, Bryan; Fukuda, Mark M. // Clinical Infectious Diseases;12/15/2010, Vol. 51 Issue 12, pe105 

    Background. Fears of emerging artemisinin resistance in western Cambodia have prompted a series of clinical trials investigating whether slow responses to antimalarial treatment can be overcome by increasing doses of drug. Methods. Patients with uncomplicated malaria were allocated 1 of 3 oral...

  • Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan. Ghanchi, Najia Karim; Ursing, Johan; Beg, Mohammad A.; Veiga, Maria I.; Jafri, Sana; Mårtensson, Andreas // Malaria Journal;2011, Vol. 10 Issue 1, p18 

    Background: Scarce data are available on Plasmodium falciparum anti-malarial drug resistance in Pakistan. The aim of this study was, therefore, to determine the prevalence of P. falciparum resistance associated polymorphisms in field isolates from southern Pakistan. Methods: Blood samples from...

  • Drug resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum malaria in Mlimba, Tanzania. Mbugi, Erasto V.; Mutayoba, Benezeth M.; Malisa, Allen L.; Balthazary, Sakurani T.; Nyambo, Thomas B.; Mshinda, Hassan // Malaria Journal;2006, Vol. 5, p1 

    Background: Sulphadoxine-pyrimethamine (SP) has been and is currently used for treatment of uncomplicated Plasmodium falciparum malaria in many African countries. Nevertheless, the response of parasites to SP treatment has shown significant variation between individuals. Methods: The genes for...

  • Dominican Republic--malaria prophylaxis recommendation (update).  // Weekly Epidemiological Record;3/18/2005, Vol. 80 Issue 11, p93 

    This article focuses on the risk of malaria in Dominican Republic. Low malaria risk exists throughout the year, especially in rural areas in the western provinces of Dominican Republic. There is no evidence of Plasmodium falciparum resistance to any antimalarial drug. Recommended prophylaxis in...

  • New strain of malaria reported in Africa. Gottlieb, Scott // BMJ: British Medical Journal (International Edition);8/4/2001, Vol. 323 Issue 7307, p251 

    Reports that a deadly strain of Plasmodium falciparum, the parasite that causes malaria, has arrived in Africa. Emergence of the strain in Asia and South America; Geneticist Carol Sibley's discovery that the parasite had reached Africa; Drug resistance of the parasite.

  • Amplification of pvmdr1 Associated with Multidrug-Resistant Plasmodium vivax. Suwanarusk, R.; Chavchich, M.; Russell, B.; Jaidee, A.; Chalfein, F.; Barends, M.; Prasetyorini, B.; Kenangalem, E.; Piera, K. A.; Lek-Uthai, U.; Anstey, N. M.; Tjitra, E.; Nosten, F.; Cheng, Q.; Price, R. N. // Journal of Infectious Diseases;11/15/2008, Vol. 198 Issue 10, p1558 

    Background. Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia. Methods. In vitro drug susceptibility and pvmdr1 genotype were determined in P. vivax field isolates from Indonesia and Thailand. Results. Increased pvmdr1 copy number was present in 21% of isolates from...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics