Risk Association between Human Leukocyte Antigen--A Allele and High-Risk Human Papillomavirus Infection for Cervical Neoplasia in Chinese Women

Chan, Denise P. C.; Tak-Hong Cheung; Tam, Ann O. Y.; Cheung, Jo L. K.; So-Fan Yim; Lo, Keith W. K.; Siu, Nelson S. S.; Zhou, Daniel X.; Chan, Paul K. S.
November 2005
Journal of Infectious Diseases;11/15/2005, Vol. 192 Issue 10, p1749
Academic Journal
To examine the association between human leukocyte antigen-A (HLA-A) allele polymorphism, human papillomavirus (HPV) infection, and risk for cervical neoplasia in Chinese women, 263 patients (155 with cervical intraepithelial neoplasia [CIN] II/III and 108 with invasive cervical cancer [ICC]) were compared with 572 controls. Overall, regardless of HPV status, a decreased risk for ICC was observed for patients with A*0207/0215N or A*2402, and an increased risk was observed for patients with A*1104. The protective association of A*0207/0215N was reproduced in HPV-16-positive patients with ICC, but not in subgroups infected with other HPV types. The risk association between A*1104 and both HPV-16 and HPV-18 was reproduced in the subgroups with CIN III/ICC. The protective association between A*2402 and HPV-16, HPV-18, HPV-52, and HPV-58 was consistently observed in all subgroups with CIN III/ICC, suggesting a linkage with a general antioncogenic genetic factor. The results of the present study indicate that HLA-A polymorphism is one of the host genetic factors that alter the risk for the development of cervical cancer in Chinese women.


Related Articles

  • Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women. Yang, Yuh-Cheng; Chang, Tzu-Yang; Chen, Tze-Chien; Lin, Wen-Shan; Chang, Shih-Chuan; Lee, Yann-Jinn // Cancer Immunology, Immunotherapy;Sep2015, Vol. 64 Issue 9, p1151 

    Cervical cancer is a multifactorial disease, and increasing evidence suggests that host immunogenetic background may contribute to its pathogenesis. Genetic variations in human leukocyte antigen (HLA) genes may alter the efficiency of immune response to human papillomavirus (HPV) antigens and...

  • Interaction between polymorphisms of the Human Leukocyte Antigen and HPV-16 Variants on the risk of invasive cervical cancer. De Araujo Souza, Patricia S.; Maciag, Paulo C.; Ribeiro, Karina B.; Petzl-Erler, Maria Luiza; Franco, Eduardo L.; Villa, Luisa L. // BMC Cancer;2008, Vol. 8, Special section p1 

    Background: Persistent infection with oncogenic types of human papillomavirus (HPV) is the major risk factor for invasive cervical cancer (ICC), and non-European variants of HPV-16 are associated with an increased risk of persistence and ICC. HLA class II polymorphisms are also associated with...

  • THE OVERALL ANALYSIS OF HPV AND HLA FOR CHINESE CERVICAL CANCERS. Yuping Wu; Qinming Zhang; Benrong Liu // Central European Journal of Public Health;2008 Supplement, Vol. 16, pS63 

    Background: Human papillomavirus (HPV) is a major risk factor for the development of cervical cancer (CC). Human leukocyte antigen (HLA) alleles have been associated with an increased or decreased risk of developing CC through infection with oncogenic forms of HPV, Objectives: The aim of this...

  • Human Leukocyte Antigen Class II and Cervical Cancer Risk: A Population-Based Study. Madeleine, Margaret M.; Brumback, Babette; Cushing-Haugen, Kara L.; Schwartz, Stephen M.; Daling, Janet R.; Smith, Anajane G.; Nelson, J. Lee; Porter, Peggy; Shera, Katherine A.; McDougall, James K.; Galloway, Denise A. // Journal of Infectious Diseases;12/1/2002, Vol. 186 Issue 11, p1565 

    The critical role of the human leukocyte antigen (HLA) system in presenting peptides to antigen-specific T cell receptors may explain why only some human papillomavirus (HPV)infected women progress to cervical cancer. HLA class II DRB 1 and DQB 1 genes were examined in 315 women with invasive...

  • Meta-Analysis on the Relationship between HLA-DRBl Gene Polymorphism and Cervical Cancer in Chinese Population. Wei, Lin-zhen; Wang, Hai-lin; Liu, Xin; Lu, Ya-peng; Xu, Fei; Yuan, Jin-qiu; Ling, Ya-qin // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    Aim: To determine the association between HLA-DRB1 haplotypes and risk of cervical cancer in unselected and samples from Chinese ethnicities. Methods: A comprehensive search for articles from their inception to April 1st, 2013 was conducted from PubMed, Medline, Elsevier Science, Springer Link,...

  • Implication of HLA-DMA Alleles in Corsican IDDM. Cucchi-Mouillot, P.; Lai, S.; Carcassi, C.; Sorba, P.; Stuart-Simoni, M.; Amoros, J.P.; Genetet, B.; Haras, D.; Contu, L. // Disease Markers;1998, Vol. 14 Issue 3, p135 

    The HLA-DM molecule catalyses the CLIP/antigen peptide exchange in the classical class II peptide-binding groove. As such, DM is an antigen presentation regulator and may be linked to autoimmune diseases. Using PCR derived methods, a relationship was revealed between DM gene polymorphism and...

  • Association of HLA Class I and II Alleles and Extended Haplotypes With Nasopharyngeal Carcinoma in Taiwan. Hildesheim, Allan; Apple, Raymond J.; Chien-Jen Chen; Wang, Sophia S.; Yu-Juen Cheng; Klitz, William; Mack, Steven J.; I-How Chen; Mow-Ming Hsu; Czau-Siung Yang; Briton, Louise A.; Levine, Paul H.; Erlich, Henry A. // JNCI: Journal of the National Cancer Institute;12/4/2002, Vol. 94 Issue 23, p1780 

    Investigates the association of human leukocyte antigen class I and II alleles and extended haplotypes with nasopharyngeal carcinoma (NPC) in Taiwan. Joint effects of alleles associated with NPC; HLA polymorphisms; Association between HLA genes and the development of NPC.

  • Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population. Lio, D.; Balistreri, C.R.; Colonna-Romano, G.; Motta, M.; Franceschi, C.; Malaguarnera, M.; Candore, G.; Caruso, C. // Genes & Immunity;Feb2002, Vol. 3 Issue 1, p20 

    Investigates the polymorphism of HFE human leukocyte antigen class I gene in Sicilian centenarians and nonagenarians. Representation of HFE alleles in different people; DNA analysis; Allele frequencies.

  • Human Leukocyte Antigen-G Genotype.  // Fertility Weekly;12/6/2004, p9 

    Discusses the study "Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcomes," by T.V.F. Hivid, et al, published in a 2004 issue of the scientific journal "Tissue Antigens." Extraction of DNA from peripheral blood lymphocytes;...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics